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OpenTrials
Completed

NCT Number: NCT03472066

Measurement of the Cervix During Pregnancy According to Age of Conization

Treatment of precancerous lesions of the cervix by conization has been shown to increase the risk of premature delivery and premature rupture of the membranes. It has now been clearly established that the cervix is a growing organ during adolescence and early adulthood, It has been hypothetized that cervical conization during the growth phase reduced its growth potential, and induced shorter cervix during the upcoming pregnancy. No studies have been conducted investigating the age at which conization no longer had an impact on cervical size during pregnancy. This will help to identify the age at conisation below which patients will be identified as being at risk event, and thus offer increased monitoring and possibly prophylactic management by programmed strapping. We propose to measure the length of the cervix of pregnant patients who have benefited from conization, which is currently recommended by the Collège National des Gynécologues Obstetriciens Français .In addition, the investigators will use a control group consisting of non-con conical, parity-matched pregnant patients in whom a cervical measurement will also be performed.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

CHU Amiens-Picardie

Amiens, 80054, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient referred since January 2008 with pregnancy between 2008 and 2017
  • Pregnancy after conisation
  • Cervix size between 21 and 24 SA before any obstetric event
  • Control group: parity matching, asymptomatic patients

Exclusion criteria

  • Threat of late miscarriage,
  • Premature rupture of membranes before cervical echography,
  • Other pregnancies after study of 1st pregnancy after conisation,
  • No measurement of the conization specimen,
  • Lost to follow-up,
  • Age <18
  • Twin Pregnancies
  • Patient under guardianship

Treatment and study plan

Previous conization

Other

a group of women who have been conized,

no previous conization

Other

group with asymptomatic patients on routine second trimester echography

Primary outcomes

  1. The main objective is to study the correlation between the size of the cervix and the age at conization. age at conization

    Time frame: 1 day

    Cervix length Measured during the second semester echography

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: MesCon

Important dates

Study start
2018
Primary completion
2022
Study completion
2022
First posted
Mar 21, 2018
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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