Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls

This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals.

Researchers will measure inflammation-related biomarkers in saliva, gingival fluid, and dental pulp samples to determine whether these substances reflect the level of inflammation.

The study also evaluates whether saliva and oral fluids could be used as simple, non-invasive tools to detect and monitor pulp inflammation.

We hypothesize that patients with pulpitis will show different biomarker levels compared with healthy controls.

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Key information

Conditions

Pulpitis Dental Pulp Diseases Healthy Stomatognathic Diseases Tooth Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Nantes University Hospital Dental Clinic

Nantes, Loire-Atlantique, 44 000, France

Location contact

Juliette Mme Jamoneau, PhD Student

CONTACT

[email protected]

0240412982

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years, male or female.
Patient consulting for symptomatic pulpitis (confirmed clinical and radiographic diagnosis) or for wisdom tooth extraction (healthy subject).
Patient able to understand the research and having signed a written consent form.
Permanent teeth only.

Exclusion criteria

Refusal to participate.
Pregnancy or breastfeeding.
Antibiotic or anti-inflammatory treatment in the week prior to sampling.
Clinically diagnosed inflammatory gingival or periodontal disease (gingivitis or periodontitis)
Chronic systemic inflammatory disease (e.g., uncontrolled diabetes, autoimmune diseases).
Patients under guardianship, conservatorship, or legal protection

Treatment and study plan

Primary outcomes

Measurement Compare LXA4 and RvE1 levels in saliva, gingival crevicular fluid, and dental pulp in patients with dental pulpitis and healthy subjects.

Time frame: Day 0 (initial visit)

Average concentration of LXA4 and RvE1 (expressed in pg/mL or ng/mL) measured by mass spectrometry in each type of biological sample, compared between the pulpitis group and the healthy group.

Study contacts

Contact information is provided by the study sponsor or research team.

Alexis Mr Gaudin, Professor

CONTACT

[email protected]

+33240412913

Sponsors and collaborators

Lead sponsor

Université de Nantes

Other

Collaborators

Nantes University Hospital

Registry information

Official study title

Strategic Inflammation Modulation and Advanced Regenerative Therapy of Dental PULP

Acronym: SMART-PULP

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2028
First posted: Mar 4, 2026
Registry last updated: Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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