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Completed

NCT Number: NCT00746044

Measurement of MRP2 Function Using Urinary Coproporphyrins

Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control. Thus it would be very useful to get an easily measurable biomarker reflecting individual's MRP2 activity. We aimed to investigate the ratio of urinary coproporphyrins I and III (UCP(I/I+III), known to be increased in patients with mutations in MRP2/ABCC2 gene.

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Key information

Conditions

Healthy Subjects

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de TOURS

Tours, 37000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • > 18 y
  • Affiliated to an health insurance

Exclusion criteria

  • Patient not able to understand or to comply to the protocol

Treatment and study plan

Primary outcomes

  1. Urinary coproporphyrins (I/I+III)ratio

    Time frame: End of three 24-hours periods

Secondary outcomes

  1. ABCC2 polymorphisms

    Time frame: At the time of entering in the study

Sponsors and collaborators

Lead sponsor

University Hospital, Tours

Other

Registry information

Official study title

Evaluation of the Ratio of Urinary Coproporphyrins I and III as a Potential Biomarker of MRP2 Function in Man

Acronym: COVOL

Important dates

Study start
2008
Primary completion
2008
Study completion
2009
First posted
Sep 3, 2008
Registry last updated
May 15, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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