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Completed

NCT Number: NCT01318967

Measurement of Kidney Blood Flow and Oxygen Levels by MRI

Comparison of renal blood flow measurements by PAH clearance and MRI

Completed

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Key information

Conditions

Chronic Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

About this study

The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

In this study, the investigators will enroll 16 men and women aged ≥ 18 years with Stage II - V chronic kidney disease (CKD). In addition, the investigators will enroll 4 subjects with a glomerular filtration rate (GFR) of greater than 60 ml/min who do not have any evidence of CKD.

Exclusion criteria

This study excludes those not suitable for MRI or for the interventional pharmacologic procedures.

Treatment and study plan

Furosemide

Drug

Renal blood flow is measured after the administration of 20 mg of furosemide during MRI scan only.

Other names: Lasix

Placebo

Other

Primary outcomes

  1. Measurement of Renal Blood Flow of the Kidney by the PAH Method

    Time frame: Renal blood flow is estimated over 1 hour by PAH

    Renal blood flow is estimated by the PAH method.

Secondary outcomes

  1. Measurement of Regional Blood Oxygenation by MRI

    Time frame: One measure after furosemide (day 1)

    Estimate of renal blood flow by using MRI scans before and after the administration of furosemide

Sponsors and collaborators

Lead sponsor

Wake Forest University

Other

Registry information

Official study title

MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation

Important dates

Study start
2010
Primary completion
2012
Study completion
2013
First posted
Mar 21, 2011
Registry last updated
Sep 7, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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