Measurement of Intestinal Permeability in Intensive Care Patients With Single or Multiple Organ Failure

Inclusion criteria

Patient with single organ failure, secondary to sepsis, hospitalized in intensive care for a foreseeable duration of > 48 hours

• SAPS2 between 20 and 40 at the sixth hour after the diagnosis of organ failure.
• Consent from the patient or their trusted person.
• Affiliation to a social security system.
• Functional digestive tract and possible feeding (per os or via a nasogastric tube whose indication was determined independently of the study's needs).

Second group of patients with multi-organ failure:

• Multi-organ failure syndrome with at least 2 organ failures, secondary to sepsis.
• SAPS2 between 60 and 80 at the sixth hour after the diagnosis of organ failure.
• Consent from the patient or their trusted person.
• Affiliation to a social security system.
• Functional digestive tract and possible feeding (conscious patient able to swallow or with a nasogastric tube whose indication was determined independently of the study's needs).

Exclusion criteria

• Pregnant and breastfeeding women;
• Minors;
• Persons under administrative and judicial supervision;
• Absence of a functional digestive tract (patient unable to swallow and absence of a nasogastric tube, contraindication to enteral feeding);
• Patients with gastroparesis;
• Refusal of the patient or their trusted person;
• Patient with a SAPS2 at the sixth hour after the diagnosis of organ failure < 20 or between 40 and 60 or > 80.