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Completed

NCT Number: NCT07024264

Measured Versus Estimated Energy Requirement in the ICU Patients

The goal of this observational study is to compare energy requirements estimated by predictive equation and indirect calorimetry across different BMI categories, and to examine how these estimates, along with early nutritional strategies and progressive caloric delivery relate to ICU outcomes. The main questions it aims to answer are:

1. To evaluate whether predictive equation and/or indirect calorimetry provides accurate caloric targets in critically ill patients. 2. To identify high-risk malnutrition patients (underweight, normal and overweight, obese) who may benefit most from IC-based measurement. 3. To investigate the impact of caloric strategies and nutritional achievement during the acute phase on the length of ICU stay.

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Key information

Conditions

Critical Illness Disease Attributes Energy Requirement Equation Indirect Calorimetry Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

20 year–105 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare

New Taipei City, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Length of ICU stay > 4 days
  • Mechanically ventilated adults (>20 y/o)
  • Tube feeding
  • At high risk of malnutrition by Global Leadership Initiative on Malnutrition (GLIM) criteria: underweight and obesity
  • Doctor's preference: cachexia, hypermetabolic status, TPN etc.,…

Exclusion criteria

  • Length of ICU stay <4 days
  • Mechanically ventilated adults (<=20 y/o)

Treatment and study plan

Total energy requirement calculated by predictive equation

Other

Critically ill patients are highly susceptible to malnutrition, making accurate caloric estimation essential to prevent both underfeeding and overfeeding during the acute phase in the ICU. Although predictive equations (PE) are widely used to estimate energy requirement, indirect calorimetry (IC) remains the gold standard. This study aimed to compare energy requirements estimated by PE and IC across different BMI categories.

Primary outcomes

  1. The primary outcome was ICU length of stay.

    Time frame: From admitted to ICU which defined as day 1, until transferred to the general wards or expired, up to 12 weeks.

    This study aimed to compare energy requirements estimated by PE and IC across different BMI categories, and to examine how these estimates, along with early nutritional strategies and progressive caloric delivery relate to the length of ICU stay.

Sponsors and collaborators

Lead sponsor

Taipei Medical University Shuang Ho Hospital

Other

Registry information

Official study title

Caloric Estimation Using Predictive Equations and Indirect Calorimetry in ICU Patients

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jun 17, 2025
Registry last updated
Jun 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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