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Completed

NCT Number: NCT07058181

Meaning-centered Intervention for Internalizing Symptoms

Young adults with internalizing symptoms will be randomly assigned to a six-session meaning-centered intervention condition or a waitlist condition. Both conditions receive the same questionnaires at baseline, post assessment (intervention condition: immediately after the final session; waitlist: four weeks after baseline), and follow-up.

The researchers hypothesize that a meaning-centered intervention for individuals with internalizing symptoms will increase participants' meaning in life and reduce their internalizing symptoms at post assessment and 4-week follow-up when compared to a waitlist condition.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Heymans Institute

Groningen, Provincie Groningen, 9712 TS, Netherlands

About this study

First-year psychology students at the University of Groningen will be screened for depressive and anxiety symptoms. Those with heightened symptoms will be invited via e-mail to participate in the study. After filling out the baseline assessment online, participants will be randomly assigned to either a meaning-centered intervention condition, which will receive a meaning-centered intervention taking place approximately every four days, or a waitlist condition, which will be assigned no task. Participants in the intervention condition will follow six 1-hour online intervention sessions led by a trainer and conduct intervention-related homework assignments. The sessions can be followed in English, Dutch, or German. The intervention aims to increase participants' meaning in life and reduce their internalizing symptoms (i.e. depressive and/or anxiety symptoms). Immediately after the final session (i.e. approximately one month after the baseline assessment), participants in the intervention condition will be asked to fill in the post assessment, which includes the same questionnaires as the baseline assessment. Participants in the waitlist control will be asked to complete the post assessment one month after their baseline assessment. One month after the post assessment, participants in both conditions are asked to fill in same set of questionnaires. Waitlist participants are offered to receive the intervention sessions after the study has finished. Participants are compensated with SONA credits.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • heightened internalizing symptoms (depressive and/or anxiety symptoms) as indicated by PHQ-4 total score of 2 or higher

Exclusion criteria

  • receiving psychotherapeutic treatment for a depressive or anxiety disorder
  • suicidality

Treatment and study plan

Meaning-centered intervention for individuals who tend to feel down or anxious

Behavioral

Meaning-centered intervention for internalizing symptoms adapted from the intervention "Meaning-centered intervention for youth worrying about their weight and shape".

  • Six 1-hour individual online sessions, approximately every 4 days
  • Sessions led by a certified trainer based on intervention manual
  • Four sources of meaning will be explored: personal life story, dealing with life's limitations, creating one's own life, and meaningful experiences
  • Participants follow intervention using intervention workbook
  • Homework assignments designed to deepen participants' experience and reflection on meaning in their daily lives

Primary outcomes

  1. Meaning in Life Questionnaire; Depression, Anxiety and Stress Scales-21

    Time frame: at baseline; post (one month after baseline); one-month follow-up (one month after post)

    questionnaire (MLQ: sum score (5-35), 7-point Likert scale (1-7), higher scores indicating higher presence of life meaning; DASS-21: sum score (0-33), 4-point Likert scale (0-3), higher scores indicating higher internalizing symptoms)

Secondary outcomes

  1. Dyscontrolled drinking; Three-dimensional meaning

    Time frame: at baseline; post (one month after baseline); one-month follow-up (one month after post)

    questionnaire (Dyscontrolled drinking: sum score (3-27), 9-point Likert scale (1-9), higher scores indicating higher dyscontrolled drinking; Three-dimensional meaning: sum score (11-77), 7-Point Likert scale (1-7), higher scores indicating higher life meaning)

Sponsors and collaborators

Lead sponsor

University of Groningen

Other

Collaborators

  • University of Amsterdam

Registry information

Official study title

A Meaning-centered Intervention for Individuals Who Tend to Feel Down or Anxious

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 10, 2025
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.