Mayo Clinic Precure - Prospective Study

The goal of this observational study is to 1) better understand and predict biological processes before disease begins or is identified, 2) study genomic and environmental contributors to disease, 3) identify ways to stop disease advancement before it becomes serious or complex, and 4) identify potential targets for disease therapy.

Participants will be asked to:

* collect biological samples, * download a mobile app, * collect speech (voice) recordings, and * complete surveys

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Key information

Conditions

Genetic Predisposition Disease Attributes Disease Susceptibility Exposure, Environmental Genetic Predisposition to Disease Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years
Registered Mayo Clinic patient
Able to provide informed written consent
Able to receive mail and packages within a United States (US) state
Able to collect and ship samples within a US state via FedEx for overnight delivery

Exclusion criteria

Active hematological cancer or history of a hematological cancer
Allogeneic Bone Marrow Transplant (autologous bone marrow transplant recipients are acceptable if collected at least one month after transplant)
Other co-morbidity that, in physician's opinion, would interfere with patient's ability to participate in the study (e.g., reduced ability to comprehend, i.e., dementia, intellectual disability, etc.)

Treatment and study plan

Primary outcomes

Build a comprehensive, multi-omics and phenotype dataset

Time frame: Up to 5 years

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2030
Study completion: 2035
First posted: Jan 12, 2026
Registry last updated: Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Enrolling by Invitation