Maximizing Acute Kidney Injury End-point Intervention Post-Discharge (MAKE-IT) Study

Participants with moderate to severe acute kidney injury (AKI) who are discharged from participating centers (the University of Alabama at Birmingham Hospital, Vanderbilt University Medical Center, University of Kentucky) will be randomized to coming to a dedicated AKI clinic at one of the three recruitment centers for up to four visits over 3 months or usual care. At the visits to the AKI follow-up clinics, medicine reconciliation will be done, blood pressure will be measured, information on hospitalizations and other adverse events will be taken and blood and urine samples will be collected to check kidney function and store samples to measure biomarkers of AKI. Participants randomized to usual care will be contacted by telephone to review medications currently being taken and to collect information on hospitalizations and other adverse events. The primary outcome measures will be include both process of care and clinical outcomes.

Inclusion criteria

• Patients age 18 years and older
• Patients who have developed moderate to severe AKI in the hospital, defined as:

• At least a doubling of peak creatinine from baseline or receipt of dialysis while in the hospital
• AKI of any degree in individuals with an estimated glomerular filtration (eGFR) rate < 60 ml/min/1.73m2 at baseline
• AKI of any degree whose discharge creatinine does not return to within 50% of baseline.
• Able to provide signed informed consent

Exclusion criteria

• Patients with a history of kidney transplant
• Patients who, in the opinion of the investigator, are not suitable to participate in the study
• Unable to obtain written informed consent
• prisoners or pregnant patients