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NCT Number: NCT06063889

Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis

This study is a detailed assessment of the maximal rate of force development of ankle muscles and its association with functional ability in patients with knee osteoarthritis (OA).

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Knee Arthritis Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

30 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Outpatient clinic of faculty of physical therapy, Ahram Canadian University

Al Ḩayy Ath Thāmin, Giza Governorate, 3221405, Egypt

About this study

This research is designed to study the link between force development in ankle muscles and functional abilities in knee OA patients. It aims to understand the influence of ankle muscle strength, specifically plantar flexors, on the stability, pain, and functionality of patients with knee OA. The study will analyze the rate of force development, its importance in explosive strength improvement, and impact on preventing knee injuries. Furthermore, it will investigate the compensatory mechanism of the plantar flexors developed by patients in advanced stages to balance other muscle failures.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Group 1 (Knee OA group)
  • Patients diagnosed with knee osteoarthritis according to Performance of the 2018 classification criteria for early stage knee OA was tested using data from the Osteoarthritis Initiative (OAI (Leung et al.,2020).
  • Grade 2-3 KOA cases according to Kelgren-Lawrance classification
  • Having knee pain for at least 6 months.
  • The visual analog scale (VAS) score being at least 3 or more.
  • Group 2 (Healthy control group) 1. Individuals with no signs or symptoms of Knee OA or other neurological or musculoskeletal conditions.

Exclusion criteria

  • Patellar subluxation
  • Surgery in any joint of the lower limb
  • Meniscal injury
  • Ligament instability
  • Patients who received intra-articular injection in the knee in the last 6 months
  • Patients with problems in the hip and ankle
  • Patients who participated in in another physical therapy program in the last 3 months were not included in the study.

Treatment and study plan

Maximal Rate of Force Development Test for Ankle Muscles

Diagnostic Test

This test is designed to measure the maximal rate of force development in the ankle muscles, specifically the plantar flexors. It aims to assess the relationship between the strength of these muscles and the functional ability in patients with knee osteoarthritis. The results from this test will help to understand how lower limb muscle strength influences the symptoms and progression of knee osteoarthritis.

Primary outcomes

  1. Knee Osteoarthritis Outcome Score (KOOS)

    Time frame: Baseline

    The KOOS is a questionnaire that assesses five aspects of knee injury and osteoarthritis: pain, symptoms, ADL function, sport and recreation function, and quality of life. Scores are transformed to a 0-100 scale, with zero representing extreme knee problems and 100 representing no knee problems. Higher scores indicate better function and less pain.

  2. Forward Step Down Test (FSDT)

    Time frame: Baseline

    This functional ability test requires participants to perform as many repetitions as possible in 30 seconds of a specific movement. The number of valid repetitions performed in this duration is recorded.

  3. Single Leg Hop Test (SLHT)

    Time frame: Baseline

    n this test, participants hop forward as far as possible on one leg, and the distance hopped is recorded.

  4. Isokinetic Testing Procedures

    Time frame: Baseline

    This procedure involves conducting tests of three (60°/s) or five (120°/s) maximal nonconsecutive efforts with specific rest intervals. Each subject is instructed to exert maximal effort throughout the whole range of motion.

  5. Rate of Force Development (RFD)

    Time frame: Baseline

    The RFD is a measure of the speed at which the force of a muscle contraction develops. It is typically measured during isometric contractions and provides information about the muscle's explosive strength capacity.

Sponsors and collaborators

Lead sponsor

Ahram Canadian University

Other

Registry information

Official study title

Assessment of Maximal Rate of Force Development of Ankle Muscles and Its Association Functional Ability in Patients With Knee Osteoarthritis

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Oct 3, 2023
Registry last updated
Aug 6, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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