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Completed

NCT Number: NCT02345876

Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children

The hypothesis of central auditory processing disorders has been advanced to explain the anomalies of the grapheme/phoneme combination in some dyslexia. These phonological disorders may be linked to abnormalities of the efferent (medial olivocochlear) system modulation and of cortical asymmetry. Indeed, the efferent system has an asymmetry in relation to handedness. Thus, in right-handed subject, it is predominant on the right side. In contrast, in the subject-handed dyslexic, the efferent system tends to be right-lateralized or non-lateralized. However, after an audio-visual training, normal lateralization can appear. This maturation of the efferent system lateralization during reading acquisition seems to have a particular profile in dyslexics with phonological disorder, especially if it is persistent. This finding allows to consider new prognostic evaluation and speech therapy rehabilitation in the dyslexic child.

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Key information

Conditions

Dyslexia Communication Disorders Language Disorders Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Specific Learning Disorder

Age range

6 year–11 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitzlier Le Vinatier, Bron, France

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Common inclusion criteria

  • Native French speaker and french education
  • No medical treatment for behavior or neurological disorders (as epilepsy)
  • Normal or corrected vision
  • Right-handed children (Edinburgh tets (Oldfield, 1971): >+50%)
  • Normal ORL examination
  • No hearing loss : hearing thresholds not above 15 dB between 250 and 4 000 Hz
  • Presence of Otoacoustic Emissions (Total amplitude < 5 dB or SNR > 3dB for at least 3 frequency bands between 1 and 4 kHz)
  • Normal level of intellectual development
  • Regular school attendance

For the normal reading children

  • Aged from 6 to less than 11
  • Normal reading level

For the dyslexic children

  • Aged from 8 to less than 11
  • Diagnostic of dyslexia made by a complet check-up during the 6 last months before the inclusion

Exclusion criteria

  • Neurological or psychiatric disease incompatible with the testing procedure
  • Ear disease during more than 6 months
  • Normal reading children who have repeat a year
  • Previous speech therapy for normal reading children
  • Not corrected visual acuteness
  • Schooling in a foreign language
  • Foreign language spoken at home with both parents
  • Known hearing deficit
  • Invalid social security

Treatment and study plan

No intervention

Other

Primary outcomes

  1. Change of The Asymmetry Index of the efferent system at 2 years interval

    Time frame: Day 1 and then at least 2 years (± 4 weeks)

    The change of the Asymmetry Index of the efferent system The Asymmetry Index is the difference between the equivalent attenuation measured on the right ear and the left ear. Evoked otoacoustic emissions were recorded monaurally at five stimulus intensities ranging from 57 to 69 dB SPL in 3 dB steps, in random presentation order, with and without contralateral acoustic stimulation consisting of 30 dBSPL continuous broadband noise (speech-like noise) produced by an audiometer

Secondary outcomes

  1. Change in the level of reading skill

    Time frame: Day 1 and then at least 2 years (± 4 weeks)

    Behavioral measure

  2. Change in the percentage of correct answers obtained during a speech perception test in silence and noise.

    Time frame: Day 1 and then at least 2 years (± 4 weeks)

    Oral repetition of VCV

  3. Change in percentage of correctly repeated stimuli which have been heard in both ears (binaural integration with divided attention) or in one indicated ear (binaural separation with selective attention)

    Time frame: Day 1 and then at least 2 years (± 4 weeks)

    Presentation of different speech material to both ears simultaneously

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Asymmetry, Auditory Processing and Reading Skills in Phonological Dyslexic Children Compared to Average-reading Children

Acronym: ASTRAUCOLE

Important dates

Study start
2014
Primary completion
2019
Study completion
2019
First posted
Jan 26, 2015
Registry last updated
Jul 18, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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