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NCT Number: NCT03633162

Maternal Grandmothers in the Born in Guangzhou Cohort Study

The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

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Key information

Conditions

Hereditary Transmission Body Weight Childhood Obesity Host and Microbiome Immune Development Neurodevelopment Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Pediatric Obesity Signs and Symptoms

Age range

36 year–100 year

Sex eligibility

Female

Study type

Observational

Primary location

Guangzhou Women and Children's Medical Center

Guangzhou, Guangdong, 510623, China

Location status: Recruiting

Location contact

Xiu Qiu, Doctor

CONTACT

[email protected]

+862038076001

About this study

It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
  • Baseline information of maternal grandmother's daughter during pregnancy available

Exclusion criteria

  • Significant cardiovascular abnormalities
  • Intelligent obstacle, intellectual disabilities or gawkish condition

Treatment and study plan

Primary outcomes

  1. Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring

    Time frame: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth

    Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers

Secondary outcomes

  1. Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life

    Time frame: At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren

    Assessed by analyses of IL-1, IL-6, IL-10, IL-12, etc.

  2. The prevalence of eczema of grandchildren

    Time frame: At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

    Assessed by self-reported time of onset and electronic medical record

  3. The incidence of asthma of grandchildren

    Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

    Assessed by self-reported time of onset and electronic medical record

  4. The prevalence of Allergic rhinitis of grandchildren

    Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

    Assessed by self-reported time of onset and electronic medical record

  5. The prevalence of Food allergy of children and grandchildren

    Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

    Assessed by self-reported time of onset and electronic medical record

  6. Changes of body composition of grandchildren

    Time frame: At age of 3 years,6 years, 12years and 18years

    Body composition is assessed using Dual Energy X-Ray Absorptiometry

  7. Changes of bone density of grandchildren

    Time frame: At age of 3 years,6 years, 12years and 18years

    Bone density is assessed using Dual Energy X-Ray Absorptiometry

Study contacts

Contact information is provided by the study sponsor or research team.

Xiu Qiu, PhD

CONTACT

[email protected]

0086 20 38367160

Xueling Wei, MS

CONTACT

[email protected]

0086 20 38367159

Sponsors and collaborators

Lead sponsor

Guangzhou Women and Children's Medical Center

Other

Collaborators

  • Children's Hospital Medical Center, Cincinnati
  • University of Birmingham

Registry information

Acronym: MGBIG

Important dates

Study start
2018
Primary completion
2025
Study completion
2038
First posted
Aug 16, 2018
Registry last updated
Oct 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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