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Completed

NCT Number: NCT04480944

Massive Burns: Retrospective Analysis of Changes in Outcomes Across 18 Years

Burns treatment and management has evolved since the 90s, particularly for massive burns (≥ 50% of total body surface area (TBSA)). This study aims at analyzing the impact of the management changes on the length of intensive care unit (ICU) stay, the take of skin grafts and the mortality.

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Key information

Conditions

Burns Critical Illness Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Adult ICU and Burn ICU, Lausanne University Hospital

Lausanne, Canton of Vaud, 1011, Switzerland

About this study

Review of all massively burned patients treated at Lausanne University Hospital burn intensive care unit (ca. 40-60 patients). Analysis of changes in length of intensive care unit stay (LICU), skin graft take rate or mortality between 2000 and 2018.

Hypothesis : the optimization of resuscitation procedures and of nutrition therapy combined with the use of novel surgical techniques has brought a significant improvement in outcomes.

Association between outcomes and year of admission will be assessed through correlation analysis and logistic regression analysis. Potential cofounders will be assessed through stepwise linear regression analysis

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All adult patients (>18 years old) with burns ≥50% TBSA admitted in the burn intensive care unit (ICU) of the Lausanne University Hospital

Exclusion criteria

  • Patients admitted in the burn center ICU with another primary diagnosis than burn (e.g. necrotizing fasciitis, gangrene, toxic epidermal necrolysis)
  • Patients referred from and/or to another ICU
  • Patients in which active withdrawal of care was decided within 48h of admission
  • Patients with first degree burns only

Treatment and study plan

Primary outcomes

  1. LICU/Percent TBSA

    Time frame: 18 years

    Ratio between the length of stay in the ICU and the total body surface area burned

Secondary outcomes

  1. Percent TBSA grafted/ Percent TBSA deep burns

    Time frame: 18 years

    Ratio between the TBSA grafted and the deep burns TBSA

  2. Daily nutritional intakes

    Time frame: 18 years

    Daily energy, proteins, lipids and carbohydrates intakes per kilogram of body weight

  3. Mortality

    Time frame: 18 years

    Percentage of patients who received maximal care and died nonetheless

Sponsors and collaborators

Lead sponsor

Mette M Berger

Other

Registry information

Official study title

Massive Burns: Retrospective Analysis of Change in Outcomes Across 18 Years

Acronym: MassiveBurns

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
Jul 22, 2020
Registry last updated
Jul 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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