Mass Spectral Fingerprinting in Obstructive Sleep Apnoea

To answer the question whether a previously detected breath profile in patients suffering from obstructive sleep apnoea (OSA) can be found in a cohort of patients with suspected OSA using mass spectrometry (validation study).

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Key information

Conditions

Obstructive Sleep Apnoea (OSA) Apnea Dyssomnias Exhaled Breath Mass Spectrometry Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Zurich, Division of Pneumology

Zurich, Canton of Zurich, 8091, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical suspicion of obstructive sleep apnoea syndrome (based on clinical symptoms such as increased daytime sleepiness; Epworth Sleepiness Score (ESS) > 10).
Age between 18 and 85 years at study entry.

Exclusion criteria

None

Treatment and study plan

Primary outcomes

OSA-specific mass spectrometric pattern of VOCs in the exhaled breath

Time frame: one hour, single measurement, no follow-up

Concentration of volatile organic compounds (VOCs) in the exhaled breath will be analysed using mass spectrometry

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

Swiss Federal Institute of Technology

Registry information

Official study title

Diagnosis of Obstructive Sleep Apnoea by Selective Secondary Electrospray Ionization - Mass Spectrometry (SESIMS)

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Jun 22, 2016
Registry last updated: Oct 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed