Marshall Vein Ethanol Infusion in Addition to Pulsed Electric Field Ablation Versus Pulsed Electric Field Ablation Alone for Paroxysmal Atrial Fibrillation

Inclusion criteria

• Age over 18 years;
• With symptomatic* paroxysmal AF;
• Undergoing first AF ablation;
• At least one AF lasting over 30s documented by 12-lead ECG, Holter, or other rhythm monitoring device in the past 12 months;
• Able to understand the purpose of the study, willing to receive randomization of the ablation strategy, and able to be followed up as required, voluntarily participate in the study and signed a written informed consent.

• Symptoms include but not restricted to palpitations, dizziness, fatigue, or shortness of breath and chest discomfort

Exclusion criteria

• Diagnosed with persistent atrial fibrillation or duration of atrial fibrillation >7 days;
• Thrombosis in the heart cavity;
• Contraindications to oral anticoagulants including the presence of a history of heparin-induced thrombocytopenia;
• Transient/reversible atrial fibrillation due to electrolyte disorders, thyroid disease or other non-cardiac-related causes;
• Acute coronary syndrome in the past 3 months or coronary intervention or coronary artery bypass treatment;
• Stroke or transient ischemic attacks (TIA) in the past 3 months;
• History of cardiac surgery or other surgical history involving left atrium, such as previous left atrial catheter ablation, atrial septal defect repair, etc.;
• History of previous severe valvular disease (severe mitral stenosis or regurgitation), congenital heart disease, hypertrophic cardiomyopathy or dilated cardiomyopathy;
• TEE examination in the past 12 months showed that the left atrium diameter of the parasternal long axis section was ≥55mm;
• Other factors that are not suitable for surgery (such as history of organ transplant surgery or ongoing evaluation of organ transplant surgery, life expectancy less than 1 year, uncontrolled cancer, pregnancy, breastfeeding, or planning to get pregnant, etc.);
• Other patients who were not suitable for enrollment in this study after the investigator's evaluation;