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Completed

NCT Number: NCT04791917

Marijuana Use, Strength Training, and Alcohol Consumption (MUSTAC) Study

Self-medication of pain by consuming alcohol and marijuana is common. However, the research regarding pain as a determinant for alcohol and marijuana use has relied on laboratory pain induction paradigms with limited clinical relevance. The study will assess demand for alcohol and marijuana before and after delayed onset muscle soreness (DOMS) induction in co-users. This will provide a clinically relevant, but time-limited, model for the effects of musculoskeletal pain on demand.

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Key information

Conditions

Chronic Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Florida Center for Pain Research and Behavioral Health

Gainesville, Florida, 32610, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 21 years;
  • English-speaking
  • Self-identify as White/Caucasian or Black/African American
  • Own a smartphone with cellular/data plan
  • Regularly co-use alcohol and smoked marijuana as indicated by scores of ≥3 on item 1 of the CUDIT-R and AUDIT.
  • Willing and able to give informed consent

Exclusion criteria

  • Participation in biceps-specific conditioning program in the past 6 months*
  • Self-reported wrist/hand, elbow, or shoulder pain the past 3 months
  • Chronic medical condition that may affect pain perception (e.g. diabetes, fibromyalgia, headaches)
  • Self-reported kidney dysfunction, muscle damage, or major psychiatric disorder
  • Medical marijuana prescription
  • Consumption of marijuana using only non-inhalational methods (e.g. edibles, tinctures, or cannabidiol oil)
  • Score of ≥ 10 on Patient Health Questionnaire-9 (moderate depression)
  • Women who are pregnant, trying to become pregnant, or breastfeeding

Treatment and study plan

Eccentric Biceps Flexion

Behavioral

Muscle lengthening biceps exercise

Concentric Biceps Flexion

Behavioral

Muscle shortening biceps exercise

Primary outcomes

  1. Alcohol Demand: Breakpoint

    Time frame: 48 hours after exercise

    Changes in breakpoint of alcohol demand, assessed using the Alcohol Purchase Task. Breakpoint indicates the drink price at which participants report no alcohol consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  2. Alcohol Demand: Omax

    Time frame: 48 hours after exercise

    Changes in Omax, assessed using the Alcohol Purchase Task. Omax reflects the highest total amount in dollars that a participant would spend on alcohol-containing beverages. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  3. Alcohol Demand: Pmax

    Time frame: 48 hours after exercise

    Changes in Pmax, assessed using the Alcohol Purchase Task. Pmax reflects the price point at which demand for alcohol becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  4. Alcohol Demand: Essential Value

    Time frame: 48 hours after exercise

    Changes in Essential Value, assessed using the Alcohol Purchase Task. Essential Value represents the reinforcing efficacy of alcohol, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.

  5. Cannabis Demand: Intensity

    Time frame: 48 hours after exercise

    Changes in intensity of cannabis demand, assessed using the Marijuana Purchase Task. Intensity reflects the number of joints that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed intensity values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  6. Cannabis Demand: Breakpoint

    Time frame: 48 hours after exercise

    Changes in breakpoint of cannabis demand, assessed using the Marijuana Purchase Task. Breakpoint indicates the joint price at which participants report no cannabis consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  7. Cannabis Demand: Omax

    Time frame: 48 hours after exercise

    Changes in Omax, assessed using the Marijuana Purchase Task. Omax reflects the highest total amount that a participant would spend on cannabis. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  8. Cannabis Demand: Pmax

    Time frame: 48 hours after exercise

    Changes in Pmax, assessed using the Marijuana Purchase Task. Pmax reflects the price point at which demand for cannabis becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.

  9. Cannabis Demand: Essential Value

    Time frame: 48 hours after exercise

    Changes in Essential Value, assessed using the Marijuana Purchase Task. Essential Value represents the reinforcing efficacy of cannabis, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.

  10. Alcohol Demand: Intensity

    Time frame: 48 hours after exercise

    Changes in intensity of alcohol demand, assessed using the Alcohol Purchase Task. Intensity reflects the number of drinks that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed number of drinks coded so that positive values indicate an increase in the demand index from baseline to follow-up.

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  • Research Society on Alcohol

Registry information

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Mar 10, 2021
Registry last updated
Jul 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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