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Completed

NCT Number: NCT00845286

Marathon, Genetics, Inflammation and the Cardiovascular System: MAGIC-Trial

The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with genotype/polymorphisms. We aim to investigate the effects of extreme endurance exercise on the cardiovascular system. Furthermore, the role of the inflammatory response and adaptive mechanisms of the vasculature are examined. Subclinical injuries to the myocardium and vascular wall are being investigated.

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Key information

Conditions

Heart Failure Behavior Cardiovascular Diseases Death Death, Sudden Death, Sudden, Cardiac Heart Arrest Heart Diseases Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Sudden Cardiac Death

Age range

30 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Prevention and Sports medicine

Munich, Bavaria, 80809, Germany

About this study

Regular exercise leads to an improvement of cardiovascular risc factors in patients with coronary heart disease, atherosclerosis and metabolic disorders. Aerobic exercise has anti-inflammatory effects. In contrast, the exertional exercise of marathon running causes an acute pro-inflammatory impulse. This may lead to myocardial injury and, in case of preexisting plaques, may result in plaque rupture and acute myocardial infarction.

We aim to define the critical role of inflammatory markers and cardiovascular risc factors as a predictor of an increased risk for myocardial and endothelial dysfunction in marathon runners.

Diagnostic tools include measurements of augmentation index (AIx), arteriolar-venular ratio (AVR) and, for the first time, 2D and 3D echocardiographic measurements such as TDI-imaging and speckle tracking. Inflammatory markers include c-reactive protein (CRP), interleukins and tumor necrosis factor. Additionally, cardiovascular markers are measured. All variations are analysed on the basis of genotype characteristics/polymorphisms.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • men aged 30-60 years

Exclusion criteria

  • manifested heart disease
  • insulin dependent diabetes mellitus
  • multi drug therapy
  • GFR<60ml/min.

Treatment and study plan

Munich Marathon

Behavioral

42,195 km marathon run

Other names: MAGIC

Primary outcomes

  1. E/A ratio

    Time frame: pre-, post-, one day follow-up

Secondary outcomes

  1. LV twist

    Time frame: pre-, post-, one day follow-up

Sponsors and collaborators

Lead sponsor

Technical University of Munich

Other

Registry information

Official study title

Investigation of Myocardial Function and Vascular Adaptation in Association With Genotype in Marathon Runners

Acronym: MAGIC

Important dates

Study start
2008
Primary completion
2014
Study completion
2014
First posted
Feb 18, 2009
Registry last updated
Mar 17, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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