Mapping Multidimensional Illness Trajectories of Patients With End-stage Kidney Disease

Patients with end-stage kidney disease (ESKD) must manage not only the demands of dialysis and comorbid conditions but also associated symptoms and acute life-threatening events that contribute to functional limitations and increased risk of mortality. Yet little is known about the trajectories of quality of life dimensions in patients with ESKD when they experience acute life-threatening episodes, to guide palliative care for this population. In this prospective, descriptive study, we will identify trajectories of symptoms, physical functioning, psychosocial needs, and emotional and spiritual well-being in 200 patients with ESKD who are at a high risk of experiencing acute life-threatening events and mortality within 12 months.

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Key information

Conditions

End Stage Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UNC Hospitals and outpatient dialysis clinics

Chapel Hill, North Carolina, 27514, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

aged 18 years or older;
receiving either Hemodialysis or Peritoneal dialysis
on dialysis either < 3 months or ≥ 6 months with a Charlson Comorbidity Index (CCI) score ≥ 5

Exclusion criteria

Patients who are enrolled in hospice or too sick to participate in questionnaire completion will not be eligible.
Kidney transplant candidates will be excluded because their illness trajectories after transplant are likely to differ.

Treatment and study plan

Primary outcomes

Symptoms, physical functioning, psychosocial needs, spiritual well-being, cognitive functioning

Time frame: 12 months

Sponsors and collaborators

Lead sponsor

University of North Carolina, Chapel Hill

Other

Collaborators

National Institute of Nursing Research (NINR)

Registry information

Official study title

Mapping Multidimensional Illness Trajectories of Patients With ESKD

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: Feb 10, 2012
Registry last updated: Sep 4, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed