Enrolling by Invitation

NCT Number: NCT07177378

Management of Medication Related Osteonecrosis of the Jaws With Double Periosteal Flap Closure

20 patients with MRONJ underwent surgical debridement using piezosurgery then closure using double periosteal flap

Enrolling by Invitation

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Key information

Conditions

Osteomyelitis of Jaw

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Tanta University

Tanta, 3111, Egypt

About this study

20 patients with MRONJ underwent surgical debridement, crestal incision and oblique releasing incision were performed to expose the area of osteomyelitis, then squesterum was removed using piezosurgery. After complete debridement, the periosteal layer was dissected from mucoperiosteal buccal flap and based superiorly, then turn upward to be sutured to the lingual flap followed by suturing of buccal flap to achieve double layers closure

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with MRONJ

Exclusion criteria

Patients had a history of radiotherapy
Patients need only conservative treatment

Treatment and study plan

management of medication related osteonecrosis of the jaw

Device

after buccal flap reflection, the bone osteonecrosis was debrided using piezosurgery. the buccal mucoperiosteal flap was dissected to two layers first, the periosteal layer was based superiorly and the mucosal flap to achieve double layers closure.

Primary outcomes

evaluation of pain

Time frame: one month

visual analog scale (VAS), with 0 indicating no pain and 10 indicating the most severe pain.
wound healing

Time frame: one -3 months

the wound healing index (WHI) which scored soft tissue healing according to the following criteria: score 1 = uneventful healing with no gingival edema, erythema, suppuration, patient discomfort, or flap dehiscence; score 2 = uneventful healing with slight gingival edema, erythema, patient discomfort, or flap dehiscence, but no suppuration; and score 3 = poor wound healing with significant gingival edema, erythema, patient discomfort, flap dehiscence, or any suppuration

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Management of Medication Related Osteonecrosis of the Jaws Using Piezosurgery With Simultaneous Double Periosteal Flap Closure

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Sep 17, 2025
Registry last updated: May 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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