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OpenTrials
Completed

NCT Number: NCT03656523

Management of Antithrombotic TherApy in Patients With Atrial Fibrillation or DevelOping AtRial Fibrillation During Hospitalization for PCI

ACS are a potent risk factor for AF, with new onset AF occurring in up to 1 in every 5 patients hospitalized with an ACS.

Despite its relatively frequent occurrence and the many etiologic factors involved in its pathogenetic condition, the frequency and prognostic significance of AF complicating ACS remain unclear

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Key information

Conditions

Acute Coronary Syndrome Arrhythmias, Cardiac Atrial Fibrillation Cardiovascular Diseases Heart Diseases Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ospedale Civile Ss. Filippo E Nicola - U.O. Cardiologia E Utic, Avezzano, AQ, Italy

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About this study

There are limited data available, particularly from a representative population-based perspective describing recent pharmacological and non-pharmacological management and clinical event rates associated with AF complicating ACS in the era of novel treatment strategies (in both AF and ACS) and high coronary reperfusion rates.

This registry will assess the current in-hospital management and clinical events at 6 months of consecutive patients admitted in Italian cardiology intensive care units (CCUs) for an ACS treated invasively with PCI and stent implantation who present AF at admission or during hospital stay, before or after stent implantation .

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All consecutive ACS patients treated with PCI with stent implantation who present AF at admission or during hospital stay, before or after stent implantation.

Exclusion criteria

  • Patients admitted with a diagnosis of ACS at the time of enrolment but not confirmed during hospitalization
  • ACS treated medically or with PCI but without stent implantation
  • Patients not giving informed consent

Treatment and study plan

Acute coronary syndrome and PCI and AF

Other

Patient with ACS and ACS treated with PCI

Primary outcomes

  1. Clinical epidemiology

    Time frame: Enrollement

    Demographics

  2. Management

    Time frame: 6 months

    Pharmacological treatment

  3. Antithrombotic strategy

    Time frame: 6 months

    Intravenous or oral antiplatelet and anticoagulation therapies and their combination

  4. Clinical epidemiology

    Time frame: Enrollement

    Clinical history

  5. Clinical epidemiology

    Time frame: Enrollement

    Type of AF

  6. Clinical epidemiology

    Time frame: Enrollement

    Type of ACS

  7. Management

    Time frame: 6 months

    Time of PCI

  8. Number of procedure performed on enrolled patients

    Time frame: 6 months

    In-hospital management

Secondary outcomes

  1. Pharmacological therapies

    Time frame: 6 months

    Use and persistence of therapies prescribed at discharge

  2. Clinical outcomes

    Time frame: 6 months

    All cause deaths, major bleedings, non fatal stroke, systemic embolism, transiet ischemic attach, MI recurrence

Sponsors and collaborators

Lead sponsor

Heart Care Foundation

Other

Registry information

Acronym: Matador-PCI

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Sep 4, 2018
Registry last updated
Feb 3, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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