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NCT Number: NCT07369427

Magnetic Tracking and ECG-Guided Tip Confirmation System for PICCs

This prospective study enrolled cancer patients who underwent peripherally inserted central catheter (PICC) placement at a tertiary care oncology hospital in Guangzhou between January 1st and May 30th, 2026. Data on catheterization outcomes and complications were collected to compare two tip positioning techniques: electromagnetic navigation tip positioning and traditional electrocardiogram (ECG)-guided positioning. The outcomes assessed included first-attempt catheterization success rate, tip positioning accuracy, catheterization procedure time, post-procedural catheter adjustment time, and the incidence of complications (thrombosis, infection, and catheter dysfunction) within 4 weeks post-catheterization.

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Key information

Conditions

Peripherally Inserted Central Catheters

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, 510000, China

Location status: Recruiting

Location contact

Zeyin Hu

CONTACT

[email protected]

15899954190

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • cancer patients receiving PICC placement
  • High risk of PICC-related thrombosis(Evaluated by Caprini score ≥ 5)
  • Agree to receive PICC maintenance at the research hospital;
  • Sign the informed consent form

Exclusion criteria

  • PICC placed in the lower limb
  • Estimated survival time less than one month

Treatment and study plan

Sherlock 3CG Tip Confirmation System

Other

Sherlock 3CG Tip Confirmation System: An integrated system combining magnetic navigation tracking and ECG guidance. It dynamically confirms the tip's position relative to the target anatomical location (e.g., superior vena cava-right atrial junction) by real-time tracking of the catheter tip's spatial position via magnetic navigation and synchronously monitoring ECG signals (e.g., P-wave changes).

Traditional ECG-Guided Tip Positioning Technology: Relying solely on ECG monitoring for guidance, it assists in determining the tip position via characteristic waveform changes in intracardiac ECG signals (e.g., changes in P-wave amplitude) derived from the catheter tip electrode as the tip approaches the target location, serving as a conventional positioning method.

Primary outcomes

  1. one time catheterization rate

    Time frame: data will be collected on Day 1

Secondary outcomes

  1. time for catheter tip positioning during catheterization

    Time frame: on Day 1

  2. time for catheter tip adjustment after catheterization

    Time frame: on Day 1

  3. rate of correct catheter tip positioning

    Time frame: on Day 1

  4. rate of PICC-related complications

    Time frame: within 4 weeks after catheterization

Study contacts

Contact information is provided by the study sponsor or research team.

Zeyin Hu, Master

CONTACT

[email protected]

+8615899954190

Sponsors and collaborators

Lead sponsor

Sun Yat-sen University

Other

Registry information

Official study title

Magnetic Tracking and Electrocardiography-Guided Tip Confirmation System for Placement of Peripherally Inserted Central Catheters

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 27, 2026
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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