Magnetic Resonance Imaging of the Lung: Oncological Applications

Lung neoplasms are characterized by a complex interaction between tumor cells and a variety of resident and infiltrating host elements, secreted factors, and extracellular matrix proteins, collectively referred to as the microenvironment. Nowadays, in the setting of lung cancer, and in particular non-small cell lung cancer (NSCLC), the evaluation of microenvironment characteristics can only be performed by a pathologist and only on histological material. By combining different MRI parameters, it may be possible to create a specific imaging "signature" for the three different immune phenotypes and thus be able to make a distinction based on MRI examination.

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Key information

Conditions

Lung Cancer (NSCLC) Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy

Location status: Recruiting

Location contact

Chandra Bortolotto

CONTACT

[email protected]

+390382503761

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Primary NSCLC of the lung (TNM 8th edition T parameter ≥T1c)
Biopsy examination of the primary tumor adequate at least for PDL-1 quantification
Staging CT scan with uncertain N parameter and definite M parameter.

Exclusion criteria

Absolute contraindications to magnetic resonance imaging or the administration of gadolinium-based contrast agents

Treatment and study plan

Primary outcomes

assessment of the ability of advanced magnetic resonance imaging techniques to distinguish between immune phenotypes in NSCLC.

Time frame: up to 36 months

Study contacts

Contact information is provided by the study sponsor or research team.

Chandra Bortolotto

CONTACT

[email protected]

+390382503761

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Policlinico San Matteo di Pavia

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2026
Study completion: 2026
First posted: Mar 20, 2026
Registry last updated: Mar 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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