Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study

Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance. Currently, the imaging method of choice to assess BAT morphology and function is 18F-FDG-PET/CT which is expensive and exposes patients or healthy volunteers to ionizing radiation, thus impeding larger prospective studies.

Magnetic resonance imaging (MRI) could constitute a suitable alternative and preliminary small-scale studies are promising.

The overall aim of this research proposal is to develop reliable magnetic resonance imaging techniques to facilitate the study of brown adipose tissue in human adults, specifically in the context of endocrine disease.

Specifically, investigators want to

1. Develop a reliable MR imaging protocol for human BAT and compare BAT volume to cold induced nonshivering thermogenesis as a measure of BAT activity. 2. Assess the intra-individual variance of BAT volume measured by MRI. 3. Evaluate direct measurement of BAT temperature by functional MRI.

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Key information

Conditions

Healthy

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Basel, Department of Endocrinology, Basel, Canton of Basel-City, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy volunteers
Age 18-40 years
Body mass index (BMI): 17.5-27 kg/m²

Exclusion criteria

known concomitant disease influencing thyroid hormone metabolism
severe diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer
known hypersensitivity to cold, e.g. primary or secondary Raynaud's syndrome
abuse of alcohol or illicit drugs
Women who are pregnant or breast feeding
Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
Previous enrolment into the current study
implanted device not compatible with MRI, e.g. pace maker

Treatment and study plan

Primary outcomes

Correlation of scBAT volume and cold induced thermogenesis as determined by indirect calorimetry

Time frame: both measurements within 2 weeks

measurement of scBAT volume and measurement of cold induced thermogenesis as determined by indirect calorimetry, both values measured in a timeframe of two weeks

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Acronym: MIBAT

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Feb 15, 2016
Registry last updated: Apr 6, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed