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NCT Number: NCT04113356

Magnetic Resonance Imaging In Acute ST-Elevation Myocardial Infarction

Cardiovascular magnetic resonance imaging enables comprehensive assessment of cardiovascular function, morphology and pathology. The investigators aim to evaluate the nature and clinical significance of magnetic resonance imaging parameters in patients presenting with first acute ST-elevation myocardial infarction.

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Key information

Conditions

Acute ST-elevation Myocardial Infarction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital for Internal Medicine III (Cardiology and Angiology), Innsbruck, Austria

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • First ST-elevation myocardial infarction according to the European Society of Cardiology/American College of Cardiology committee criteria
  • Primary percutaneous coronary intervention within 24 hours after symptom onset

Exclusion criteria

  • Age < 18 years
  • Any history of a previous myocardial infarction or coronary intervention
  • Clinically unstable patients (Killip class >2)
  • Renal failure (estimated glomerular filtration rate < 30 ml/min/1.73 m2)
  • Contraindications to cardiac magnetic resonance imaging (pacemaker, cerebral aneurysm clip, orbital foreign body, known or suggested contrast allergy to gadolinium, claustrophobia)
  • Inability to provide informed consent

Treatment and study plan

cardiovascular magnetic resonance imaging

Diagnostic Test

Cardiovascular magnetic resonance imaging will be performed within the first week after ST-elevation myocardial infarction and in a defined subgroup 4 months, 12 months and 10 years thereafter.

Primary outcomes

  1. Occurence of major adverse cardiovascular events

    Time frame: 1 - 5 years

Secondary outcomes

  1. Infarct size assessment (% of left ventricular myocardial mass)

    Time frame: baseline, 4 months and 12 months

  2. Assessment of infarct transmurality grade (%) with late gadolinium enhancement imaging

    Time frame: baseline, 4 months and 12 months

  3. Occurence and area of microvascular obstruction

    Time frame: baseline

  4. Intramyocardial haemorrhage assessed by T2* imaging

    Time frame: baseline, 4 months and 12 months

  5. Tissue characterisation by T1, T2 and T2* Mapping

    Time frame: baseline, 4 months and 12 months

  6. Myocardial deformation by strain analysis

    Time frame: baseline, 4 months and 12 months

  7. Chamber volumes by cine imaging

    Time frame: baseline, 4 months and 12 months

  8. Cardiac function by cine imaging

    Time frame: baseline, 4 months and 12 months

  9. Stroke volumes by phase contrast imaging

    Time frame: baseline, 4 months and 12 months

  10. Aortic pulse wave velocity and distensibility by phase contrast imaging

    Time frame: baseline, 4 months and 12 months

  11. Aortic pulse wave distensibility by phase contrast imaging

    Time frame: baseline, 4 months and 12 months

  12. Quality of life and invalidity assessment (Global Physical Activity Questionnaire)

    Time frame: 1 - 5 years

  13. Biomarker release during the acute and subacute phase

    Time frame: baseline, 4 months and 12 months

    biomarker concentrations of hemodynamic stress (n-terminal pro-B-type natriuretic peptide), neurohumoral markers (i.e. neprilysin ng/ml), inflammatory markers (i.e. procalcitonin µg/l) and markers of myocardial injury (i.e. high sensitivity cardiac troponin T ng/l)

  14. Parameters of cardiac function by transthoracic echocardiography

    Time frame: baseline, 4 months and 12 months

  15. Plaque volume by 3D ultrasound

    Time frame: baseline, 12 months

  16. Cardiac autonomic function

    Time frame: baseline, 4 months and 12 months

    Deceleration capacity of heart rate

  17. Cardiac autonomic function

    Time frame: baseline, 4 months and 12 months

    Heart rate variability

  18. Cardiac autonomic function

    Time frame: baseline, 4 months and 12 months

    Periodic repolarization dynamics

  19. Cardiac autonomic function

    Time frame: baseline, 4 months and 12 months

    Baroreflex sensitivity

  20. Cardiac autonomic function

    Time frame: baseline, 4 months and 12 months

    Skin sympathetic nerve activity

Study contacts

Contact information is provided by the study sponsor or research team.

Bernhard Metzler, MD, MSc

CONTACT

[email protected]

Gert Klug, MD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Medical University Innsbruck

Other

Registry information

Official study title

Clinical Relevance of Magnetic Resonance Imaging in Acute ST-Elevation Myocardial Infarction

Acronym: MARINA-STEMI

Important dates

Study start
2011
Primary completion
2026
Study completion
2031
First posted
Oct 2, 2019
Registry last updated
Sep 10, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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