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Completed

NCT Number: NCT05858957

Magnesium Sulphate and Extubation Quality

The investigators aimed to search effect of magnesium Sulfate on extubation quality scores, recovery and pain in larynx micro surgery. The patients allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Extubation quality scores, Extubation time, NRS scores were assessed.

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Key information

Conditions

Perioperative Complication

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Cukurova University

Adana, 01380, Turkey (Türkiye)

About this study

The investigators aimed to search effect of magnesium sulfate on extubation quality, recovery feature and complications.98 adult patients scheduled for larynx laser microsurgery were included and randomly allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Paracetamol 15 mg/kg applied to all patients.Extubation quality score, extubation time, stay in postanesthesia unit (PACU) time, numeric rating scale (NRS) and complications were recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 age over
  • American society of Anesthesiology (ASA) clinical status I-III
  • the patients who experience larynx micro surgery

Exclusion criteria

  • under 18 years old
  • ASA IV and over
  • severe airway obstruction
  • neuromuscular disease
  • presence of tracheostomy

Treatment and study plan

Magnesium sulfate

Drug

magnesium sulphate IV 30 mg/kg (10 min) infusion apply to the Group M

Other names: Intravenous magnesium infusion

Saline

Drug

100 ml saline infusion apply to the Group S

Other names: Saline infusion

Primary outcomes

  1. extubation quality scores

    Time frame: at the time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).

    Extubation quality will assess with quality scores such as no cough, Mild cough, moderate cough, severe cough.

Secondary outcomes

  1. extubation time

    Time frame: time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).

    The time need to adequate spontaneous ventilation at recovery period

Sponsors and collaborators

Lead sponsor

Cukurova University

Other

Registry information

Official study title

The Effect of Magnesium Sulfate on Extubation Quality Score and Recovery in Larynx Laser Microsurgery, Prospective, Randomized, Controlled Study

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
May 15, 2023
Registry last updated
Jan 17, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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