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OpenTrials
Completed

NCT Number: NCT00833092

Magnesium Nutrition and Sleep Behavior in Older Adults

Insomnia is not a natural part of aging but is higher in older adults because of a variety of factors common in later life. One of these factors may be a deficient magnesium status. This study will look at whether or not magnesium supplementation will improve sleep.

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Key information

Conditions

Nutritional Deficiency Dyssomnias Insomnia Malnutrition Mental Disorders Nervous System Diseases Nutrition Disorders Nutritional and Metabolic Diseases Sleep Disorders, Intrinsic Sleep Initiation and Maintenance Disorders Sleep Wake Disorders

Age range

51 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

USDA Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, 58202, United States

About this study

Insomnia affects approximately one-third of older Americans. More than half of all people aged 65 and older experience sleep problems. The prevalence of insomnia and other sleep disorders is not a natural part of aging but is high in older adults because of a variety of factors common in late life. One of those factors may be a deficient magnesium status. There is a close association between sleep architecture, especially slow wave sleep, and activity in the glutamatergic and gamma-aminobutyric acid (GABA) system. Because magnesium is a natural N-methyl-D-aspartate (NMDA)antagonist and GABA agonist, magnesium apparently plays a key role in the regulation of sleep. Such a role is supported by supplementation, correlation, and animal studies showing that magnesium intake or status affects sleep organization.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • have sleep complaints
  • Score greater than 5 on Pittsburgh Global Sleep Quality Index

Exclusion criteria

  • taking medications that affect sleep
  • taking 100 milligrams or more of magnesium
  • body mass index of 40 or higher
  • abnormal breathing conditions

Treatment and study plan

Sugar Pill

Dietary Supplement

Sugar pill supplementation for 9 weeks

magnesium

Dietary Supplement

300 milligrams daily for 8 weeks

Primary outcomes

  1. Global Pittsburgh Sleep Quality Index

    Time frame: 9 weeks

    Improvement in the Pittsburgh Global Sleep Quality Index (PGQI). The index is based on a score of 0 to 21, the lower the score on the index the better the subject perceives their sleep.

Sponsors and collaborators

Lead sponsor

USDA Grand Forks Human Nutrition Research Center

Fed

Registry information

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Jan 30, 2009
Registry last updated
Mar 26, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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