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Completed

NCT Number: NCT05102058

Magnesium and Dexmedetomidine in Pheochromocytoma

Anesthesia management of pheochromocytoma excision surgery is associated with severe hemodynamic fluctuations.The objective of this study was to compare the hypertensive episodes requiring sodium nitroprusside administration between the group treated with magnesium-dexmedetomidine and conventional group in pheochromocytoma.

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Key information

Conditions

Phaeochromocytoma Crisis Hemodynamic Instability Neoplasms Neoplasms by Histologic Type Neoplasms, Germ Cell and Embryonal Neoplasms, Nerve Tissue Neuroectodermal Tumors Neuroendocrine Tumors Paraganglioma Pheochromocytoma

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists classification (ASA) 1-3
  • high urinary catecholamine or metabolites
  • tumor sizes < 5 cm
  • body mass index (BMI) <35 kg/m2

Exclusion criteria

  • open surgery
  • bilateral masses
  • tumor larger than 5 cm
  • incomplete data

Treatment and study plan

Magnesium-Dexmedetomidine

Drug

Received oral 300 mg magnesium one week before surgery and magnesium-dexmedetomidine combination perioperatively

Primary outcomes

  1. Sodium nitroprusside (SNP) requirement

    Time frame: intraoperative period

    intraoperative hypertensive episodes requiring SNP therapy

Secondary outcomes

  1. vasoactive therapy

    Time frame: intraoperative period

    hemodynamic fluctuations (hypotension, tachycardia, severe hypertensive crisis) which needed vasoactive therapy.

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

Magnesium and Dexmedetomidine Combination Reduces Sodium Nitroprusside Requirement in Laparoscopic Pheochromocytoma

Important dates

Study start
2011
Primary completion
2020
Study completion
2020
First posted
Nov 1, 2021
Registry last updated
Nov 1, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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