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Completed

NCT Number: NCT04091997

Macrophage Migration Inhibitory Factor for Diagnosing Endometriosis and Its Severity

Endometriosis is a chronic disease affecting women of reproductive age. Macrophage migration inhibitory factor (MIF) is one of non-invasive blood biomarker that was detected in sera of endometriotic patients.The aim of this study was to evaluate the value of serum macrophage migration inhibitory factor in diagnosing endometriosis in women with infertility and chronic pelvic pain and correlate its level with the stage of the disease. Three hundred patient candidate for diagnostic laparoscopy were included in a case-control observational study

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Key information

Conditions

Endometriosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases

Age range

19 year–40 year

Sex eligibility

Female

Study type

Observational

About this study

observational case-control study conducted in Fayoum University hospital from March 2016 till September 2018. Three hundred women candidate for diagnostic laparoscopy for either infertility or gynecologic chronic pelvic pain were included. The study group included patients with diagnostic criteria of endometriosis. The control group included other causes of infertility or pelvic pain.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • postmenstrual women
  • in childbearing period,
  • presenting with either gynecologic chronic pelvic pain (CPP) or infertility
  • indicated and fit for diagnostic laparoscopy.
  • All women must have no hormonal treatment for the last 3 months and.

Exclusion criteria

  • Women with bleeding tendency,
  • suspicious of gynecologic malignancy or
  • active infection

Treatment and study plan

serum Eliza assay

Diagnostic Test

laparoscopy and biopsy of lesions in endometriotic patients and seum ELIZA assay of microphage migration inhibitory factor

Other names: laparoscopy

Primary outcomes

  1. level of serum macrophage migration inhibitory factor and stage of the disease

    Time frame: one year

    serum MIF is a promising marker for noninvasive diagnosis of severity of endometriosis

Sponsors and collaborators

Lead sponsor

Fayoum University Hospital

Other

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2018
First posted
Sep 17, 2019
Registry last updated
Sep 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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