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OpenTrials
Completed

NCT Number: NCT01366794

Macronutrients and Gut Hormone Secretion

Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.

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Key information

Conditions

Type 2 Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

35 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Clinical Sciences Lund, Lund University, Lund, Sweden

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About this study

In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy status or type 2 diabetes with dietary regulation

Exclusion criteria

  • Liver disease
  • kidney disease
  • thyroid disease

Treatment and study plan

Macronutrients

Other

Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal

Other names: Glucose, Protein mixture, Fat emulsion, Mixed meal

Primary outcomes

  1. Release of gut hormones

    Time frame: 300 min

Secondary outcomes

  1. Insulin secretion

    Time frame: 300 min

Sponsors and collaborators

Lead sponsor

Lund University

Other

Registry information

Official study title

Effects of Macronutrients on Gut Hormone and Islet Hormone Secretion in Healthy Volunteers and Type 2 Diabetes

Important dates

Study start
2011
Primary completion
2012
Study completion
2013
First posted
Jun 6, 2011
Registry last updated
Mar 17, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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