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OpenTrials
Completed

NCT Number: NCT05662969

Machine Perfusion in High vs Low/Mid-volume Liver Transplant Centers: a Multicentre Survey

Introduction: Machine perfusion (MP) was developed to expand the available donor pool and to improve liver transplantation outcomes. Despite optimal results in clinical trials, MP benefit outside of clinical experimentation in unknown. Low/mid volume centres (L/MVCs) may face logistical/economical difficulties that may in turn hamper optimal MP results.

Methods: An Online 22-item survey on the use of machine perfusion for liver transplantation outside of clinical trials, was distributed to worldwide LT centres representatives. Variables of interest included MP logistics, MP technicalities, MP results, post-MP LT results. Responding centres were grouped into high volume centre (HVCs)(defined as >60 LTs per year in 2019) and L/MVCs. Results from HVCs vs L/MVCs were compared.

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Key information

Conditions

Organ Preservation Solution

Sex eligibility

All sexes

Study type

Observational

Primary location

Roberta Angelico

Rome, 00133, Italy

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • LT centres that use MP
  • LT centres which perform LT before pandemic time (before 2019 included)
  • LT centres which perform LT from cadaveric donors and living donors

Exclusion criteria

  • LT centres that not use MP
  • LT centres that use MP but on clinical trials

Treatment and study plan

Machine Perfusion

Device

Different outcomes of MP use in low/mid-volume and high-volume LT centres

Primary outcomes

  1. Liver transplant(LT) centres different use of graft after utilization of machine perfusion (MP)

    Time frame: 12/2021 - 03/2022

    High Volume Centers and Low/Mid Volume centers differ in their rates of graft utilization after Machine perfusion

Secondary outcomes

  1. Liver Transplant outcomes after Machine Perfusion

    Time frame: 12/2021 - 03/2022

    Reported patient survival rates for Liver Transplant after Machine Perfusion

Sponsors and collaborators

Lead sponsor

Roberta Angelico

Other

Registry information

Official study title

Machine-perfusion for Liver Transplantation in High Versus Low/Mid-volume Centres: an International Multicentre Survey

Acronym: MP-LTx

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Dec 23, 2022
Registry last updated
Dec 23, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.