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Completed

NCT Number: NCT04757194

Machine Learning Assisted Differentiation of Low Acuity Patients at Dispatch

BACKGROUND:

At Emergency Medical Dispatch (EMD) centers, Resource Constrained Situations (RCS) where there are more callers requiring an ambulance than there are available ambulances are common. At the EMD centers in Uppsala and Västmanland, patients experiencing these situations are typically assigned a low-priority response, are often elderly, and have non-specific symptoms. Machine learning techniques offer a promising but largely untested approach to assessing risks among these patients.

OBJECTIVES:

To establish whether the provision of machine learning-based risk scores improves the ability of dispatchers to identify patients at high risk for deterioration in RCS.

DESIGN:

Multi-centre, parallel-grouped, randomized, analyst-blinded trial.

POPULATION:

Adult patients contacting the national emergency line (112), assessed by a dispatch nurse in Uppsala or Västmanland as requiring a low-priority ambulance response, and experiencing an RCS.

OUTCOMES:

Primary:

1. Proportion of RCS where the first available ambulance was dispatched to the patient with the highest National Early Warning Score (NEWS) score

Secondary:

* Difference in composite risk score consisting of ambulance interventions, emergent transport, hospital admission, intensive care, and mortality between patients receiving immediate vs. delayed ambulance response during RCS. * Difference in NEWS between patients receiving immediate vs. delayed ambulance response during RCS.

INTERVENTION:

A machine learning model will estimate the risk associated with each patient involved in the RCS, and propose a patient to receive the available ambulance. In the intervention arm only, the assessment will be displayed in a user interface integrated into the dispatching system.

TRIAL SIZE:

1500 RCS each consisting of multiple patients randomized 1:1 to control and intervention arms

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Västmanland hospital Västerås, Västerås, Västmanland County, Sweden

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Identification of a resource constrained situation by ambulance director (i.e., 2 or more patients awaiting an ambulance response)
  • Assigned priority 2A or 2B (Low-priority ambulance response) by dispatch nurse call-taker
  • Valid Swedish personal identification number collected at dispatch
  • Age >= 18 years

Exclusion criteria

  • Relevant calls received more than 30 minutes apart
  • Logistical factors (eg. the patients' geographical locations) affect the ambulance assignment decision
  • On scene risk factors (eg. a patient is outdoors and risks hypothermia) or risk mitigators (eg. healthcare staff already on-scene with a patient) affect the ambulance assignment decision

Treatment and study plan

openTriage - Alitis algorithm

Diagnostic Test

A machine learning algorithm (Gradient boosting) applied to structured data collected in the Alitis Clinical Decision Support system, patient demographics, and free-text notes.

Primary outcomes

  1. Proportion of RCS where the first available ambulance was dispatched to the patient with the highest National Early Warning Score (NEWS).

    Time frame: Upon ambulance response (Within 8 hours of dispatch)

    NEWS is a widely used and well-validated scoring algorithm based on objective patient vital signs, which are not causally dependent on the outcomes used to train the machine learning models investigated in this study. NEWS values will be based on the first set of vital signs obtained by ambulance nurses upon making contact with the patient. NEWS is measured on a 0-21 scale, with higher values corresponding to patients at higher risk for deterioration.

Secondary outcomes

  1. Difference in composite outcome measure score between patients with immediate vs. delayed response.

    Time frame: Up to 30 days

    This measure investigates a composite score consisting of the outcomes used to train the machine learning models. The composite score is generated by identifying the following patient outcomes and assigning the corresponding weights:

    Abnormal intitial Arway/Breathing/Circulation findings by ambulance crew (4) Emergent (lights and sirens) transport to the hospital (2) Provision of prehospital interventions (1) Admission to in-patient care or mortality within 30 days (1)

    This results in a score from 0-8, with higher scores representing more

  2. Difference in National Early Warning Score (NEWS) between patients with immediate vs. delayed response.

    Time frame: Upon ambulance response (Within 8 hours of dispatch)

    Per primary outcome

Sponsors and collaborators

Lead sponsor

Uppsala University Hospital

Other

Collaborators

  • Region Västmanland

Registry information

Official study title

Machine Learning Assisted Differentiation of Low Acuity Patients at Dispatch: A Randomized Controlled Trial

Acronym: MADLAD

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Feb 17, 2021
Registry last updated
Jan 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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