Lymphatic and Systemic Immunity Changes in Post-radiation Lymphedema Development

Inclusion criteria

• Participants must be at least 18 years of age
• Participants must have been clinically diagnosed with breast cancer and scheduled for axillary lymph node dissection (ALND) and radiation treatment at MD Anderson (receiving chemotherapy, mastectomy or breast-conserving surgery, ALND (>10 nodes) and radiation treatment for breast cancer, identified by Drs. Mittendorf and Shaitelman of the Nellie B. Connally Breast Cancer Center at MD Anderson)
• Ambulatory and possessing all four limbs
• No prior radiation therapy
• Negative urine pregnancy test within 36 hours prior to study drug administration, if of childbearing potential
• Females participants must complete the Female Enrollment Form. Childbearing potential participants must agree to use one of the medically accepted forms of contraception for a period of one month after study participation. Female participants who meet the criteria for non-childbearing will still complete the Female Enrollment Form, but are not restricted to the use of contraception following study participation.

Exclusion criteria

• Participants with a known or suspected allergy to iodine
• Participants who are breastfeeding, pregnant or trying to become pregnant
• Severe underlying chronic illness or disease (other than breast cancer)
• Participants not capable of keeping moderately still for the imaging portion of the study session (~1 hour for imaging)