Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy

Stereotactic Ablative Radiotherapy (SABR), also called stereotactic body radiation therapy (SBRT), is a relatively recent advance in radiotherapy which allows high doses of radiation to be transmitted to focused areas (typically malignancies), allowing higher rates of tumoricidal activity, generally lower complications, and greater convenience for patients since it can be delivered in 1 to just a few sessions. As the radiation is administered from multiple directions according to stereotactic planning, high doses can be delivered to the tissues with rapid fall-off to relatively low doses in even nearby, surrounding normal tissues. This technique was initially applied to brain tumors- an application which over the years has met with great success. More recently, it has been applied with substantial success and is gaining increasing acceptance as a primary mode of therapy for stage I lung malignancies, and malignancies in multiple other body areas.

In the lung, the rate of pneumonitis resulting from SABR is far lower than the rates incurred by conventional external beam radiotherapy. In conventional external beam radiotherapy reported pneumonitis rates range from 13-37% (7), depending on dose and field size. Reported rates of symptomatic pneumonitis after lung SABR are significantly lower and generally are ~5% (8). SABR does, however, typically leave a scar in the area of lung that has been treated (9). Importantly, there appears to be contraction of surrounding lung parenchyma into this scar resulting in an effect that is essentially a "lung volume reduction." One often sees clear loss of lung volume following any form of lung radiotherapy. With SABR, this "volume reduction" is achieved with a far lower risk of morbidity - in particular, less risk of pneumonitis.

Inclusion criteria

Pulmonary Function:

• Severe COPD with severe reduction in quality of life due to dyspnea
• Moderate to Severe emphysematous destruction of lung parenchyma on chest CT

• FEV1 < 45% predicted and >18% predicted
• FEV1/FVC < .7
• DLCO > 18% predicted
• Residual Volume > 160% predicted (by plethysmography)

Arterial Blood Gas:

• paO2>40 on room air at rest
• paCO2<55

General:

• Successful completion of 16 sessions of pulmonary rehabilitation

Exclusion criteria

• Predominate chronic bronchitis (none or mild emphysematous destruction of lung on chest CT).
• Pulmonary function tests / lung volumes that do not meet above criteria.
• Active coronary ischemia (stress test required if clinical symptoms).
• Inability to complete 16 sessions of pulmonary rehabilitation.
• Pregnancy.
• Presence of lung cancer.