Completed

NCT Number: NCT05816239

LUng voluMe reductIoN by DuAl ENergy CT Evaluation (LUMINANCE) Study

The purpose of this research study is to see if a special CT scan (dual-energy CT) provides useful information in patients undergoing bronchsoscopic lung volume reduction (valve placement for emphysema). The investigators will enroll up to 30 participants in this study from University Hospitals Cleveland Medical Center. All of the participants from this study will undergo their valve procedure at University Hospitals Cleveland Medical Center.

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Key information

Conditions

Lung Perfusion

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients (≥ 18 years of age at the time of written informed consent) with emphysema who have been deemed appropriate candidates for bronchoscopic lung volume reduction

Exclusion criteria

Patients unable to provide consent
Patients who are pregnant or nursing
Women of child-bearing age will undergo pregnancy tests based on University Hospital (UH) standard bronchoscopy pre-procedural testing
Patients unable to undergo a DECT chest (contraindications to a CT chest with intravenous contrast such as a reported or documented allergy to intravenous (IV) contrast or impaired renal function, defined as the following:
Glomerular filtration rate (GFR) <90 ml/min/1.73 m2 at the time of initial evaluation if patient age is ≤ 59 years
GFR <85 ml/min/1.73 m2 if patient age is 60-69 years
GFR <75 ml/min/1.73 m2 if patient age is ≥70 years

Treatment and study plan

Dual Energy CT

Procedure

Patient will receive Dual Energy CT

Primary outcomes

Change in lung perfusion as measured by duel-energy computed tomography

Time frame: Baseline, 8 weeks
Change in walk distance as measured by six-minute walk test

Time frame: Baseline, 8 weeks
Change in FEV1 as measured by pulmonary function test

Time frame: Baseline, 8 weeks

Sponsors and collaborators

Lead sponsor

Sameer Avasarala

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2025
Study completion: 2025
First posted: Apr 18, 2023
Registry last updated: Sep 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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