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Completed

NCT Number: NCT04393402

Lung Ultrasound Score in Covid 19 Infectious Disease in Critical Care (LUS-COVID19)

It might be necessary with Sars-Cov2 pneumopathy patient to repeat thoracic images, the tomodensitometry ones in particular. This task is difficult and nearly impossible for several reasons: respiratory and hemodynamic unstable patient, prone position and due to the high contagious nature of the disease.

The lung ultrasound is an easy tool, fast (between 5 and 10 minutes) and as a limited training.

In the context of the Sars-Cov2 epidemic, Buonsenso and al case report depict the first lung ultrasound for a Covid 19 patient.

Peng and al in Intensive Care Medicine accentuate the usefulness of this particular technic.

In the American Journal of Respiratory and Critical Care Medicine, a study has been published as a point-of-care, in which the doctors reported using the lung ultrasound with intensive and critical care patient.

In Critical Care 2016, it has been showed that ultrasound allowed with neat precisions, to predict severe ARDS patient response to the prone position, all-cause.

Another researchers team found a good correlation between lung ultrasound, the SOFA, APACHE II, CPIS score, and patient mortality.

And a new applicability in the pulmonary recruitment by PEEP titration has been presented.

The aim of this study is to evaluate the lung ultrasound in Covid19 ARDS.

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Key information

Conditions

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nice

Nice, 06202, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed Sars-Cov2 patient, with PCR method qualitative or quantitative as usual.
  • Intensive or critical care admission
  • ARDS with PaO2/FiO2 <300 at the admission
  • Ventilatory support or oxygen-therapy

Exclusion criteria

  • Age < 18 years-old
  • Pregnancy
  • Patient with tutor- or curatorship or in prison

Treatment and study plan

lung ultrasound (LUS)

Procedure

Patients with Covid-19 Disease and admitted in critical care unit will be performed a LUS

Primary outcomes

  1. LUS applicability with COVID 19

    Time frame: 10 months

    In dorsal position, or in prone position, the two hemithorax will be subdivided in 6 parts, and a score will be attributed with the following criteria : A-Lines (0 point), > 3 B-lines (1 point), B-Lines coalscent (2 points), and pulmonary consolidation (3 points). For the echography we can use a convexe sonde, or a "cardiac" sonde.

Secondary outcomes

  1. Radiographic correlation (chest Xray and tomodensitometry)

    Time frame: 10 months

    Comparison between Xray / CT scan exam and LUS

  2. LUS Mortality prediction

    Time frame: 10 months

    according to LUS score, ventilatory mode and parameters, medical history and bood analysis results

  3. Prediction of Prone position response

    Time frame: 10 months

    comparison of LUS score depending of the position used for performing LUS

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Lung Ultrasound Score in Covid 19 Infectious Disease in Critical Care

Acronym: LUS-COVID19

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
May 19, 2020
Registry last updated
Apr 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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