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NCT Number: NCT07515001

Lung Ultrasound Score and Postoperative Pulmonary Complications in Major Non-Thoracic Surgery

This prospective observational cohort study aims to evaluate the predictive value of perioperative lung ultrasound (LUS) score in determining early postoperative oxygen requirement and pulmonary complications in patients undergoing major non-thoracic surgery. Postoperative pulmonary complications remain a significant cause of morbidity and mortality in surgical patients. Lung ultrasound is a non-invasive, bedside imaging modality that allows real-time assessment of lung aeration and pathology. This study will investigate the association between perioperative LUS score and early postoperative respiratory outcomes, including oxygen requirement and pulmonary complications.

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Key information

About this study

Postoperative pulmonary complications are among the most common causes of postoperative morbidity and prolonged hospital stay following major surgery. Early identification of patients at risk is crucial for timely intervention and improved outcomes. Lung ultrasound (LUS) has emerged as a reliable, non-invasive, and bedside tool for evaluating lung aeration and detecting pulmonary abnormalities such as atelectasis, interstitial syndrome, and pleural effusion.

This prospective observational cohort study is designed to assess the predictive value of perioperative lung ultrasound score in patients undergoing major non-thoracic surgery. A total of 97 patients aged between 18 and 65 years will be included. Lung ultrasound examinations will be performed perioperatively, and LUS scores will be calculated based on standardized protocols.

The primary objective of this study is to evaluate the relationship between perioperative LUS score and early postoperative oxygen requirement. Secondary objectives include assessing the association between LUS score and the incidence of postoperative pulmonary complications, need for intensive care unit admission, and length of hospital stay.

By identifying the predictive role of lung ultrasound scoring, this study aims to contribute to improved perioperative risk stratification and support the use of lung ultrasound as a practical tool in routine anesthetic and surgical care.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 to 65 years
  • Scheduled for elective major non-thoracic surgery
  • Undergoing surgery under general anesthesia
  • Expected surgical duration of 3 hours or longer
  • ASA physical status I-III
  • Willing to participate in the study
  • Provides written informed consent

Exclusion criteria

  • Patients undergoing thoracic or cardiac surgery
  • Advanced chronic lung disease (e.g., severe COPD or pulmonary fibrosis)
  • History of previous lung resection
  • Preoperative pneumonia or active pulmonary infection
  • Body mass index greater than or equal to 40 kg/m2
  • Pregnancy
  • Emergency surgery
  • Planned postoperative mechanical ventilation or intensive care unit admission
  • Refusal to participate in the study

Treatment and study plan

Primary outcomes

  1. Early Postoperative Oxygen Requirement

    Time frame: Within the first 24 hours after surgery

    Assessment of the need for supplemental oxygen in the first 24 hours postoperatively and its association with perioperative lung ultrasound score.

Secondary outcomes

  1. Postoperative Pulmonary Complications

    Time frame: Within 7 days after surgery

    Incidence of postoperative pulmonary complications including atelectasis, pneumonia, pleural effusion, respiratory failure, pneumothorax, acute respiratory distress syndrome (ARDS), pulmonary edema, and need for reintubation.

  2. Correlation Between LUS Score and Hypoxemia

    Time frame: Within 24 hours after surgery

    Evaluation of the relationship between perioperative lung ultrasound score and postoperative hypoxemia.

  3. Number of participants requiring ICU admission

    Time frame: Within 7 days after surgery

    Requirement for postoperative intensive care unit admission.

  4. Length of Hospital Stay

    Time frame: From surgery until hospital discharge (up to 30 days)

    Total duration of hospitalization measured in days.

  5. Duration of Postoperative Oxygen Therapy

    Time frame: Within the first 24 hours after surgery

    Total duration of supplemental oxygen therapy required during the first 24 hours postoperatively.

  6. Number of participants requiring high-flow nasal oxygen or noninvasive ventilation

    Time frame: Within 7 days after surgery

    Requirement for advanced respiratory support including high-flow nasal oxygen or noninvasive ventilation in the postoperative period.

Study contacts

Contact information is provided by the study sponsor or research team.

Huseyin Cetik, MD

CONTACT

[email protected]

+90 538 970 0171

Sponsors and collaborators

Lead sponsor

Dicle University

Other

Registry information

Official study title

Predictive Value of Perioperative Lung Ultrasound Score for Early Postoperative Oxygen Requirement and Pulmonary Complications in Patients Undergoing Major Non-Thoracic Surgery

Acronym: LUS-POSTOP

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Apr 7, 2026
Registry last updated
Apr 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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