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Recruiting

NCT Number: NCT03431064

Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.

It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.

Recruiting

Interested in participating?

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Key information

Age range

Up to 17 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Boston Children's Hospital

Boston, Massachusetts, 02115, United States

Location status: Recruiting

Location contact

Viviane Nasr, MD

CONTACT

[email protected]

617-355-6225

About this study

In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.

It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 0 to < 18 years old
  • Undergoing surgery at Boston Children's Hospital under general anesthesia
  • mechanically ventilated with an endotracheal tube
  • Monitored with an indwelling radial arterial catheter as part of the anesthetic plan for the scheduled surgical procedure

Exclusion criteria

  • Prematurity
  • Low birth weight
  • Congenital heart disease
  • Left or right ventricular dysfunction
  • Cardiac arrhythmia
  • Pulmonary hypertension
  • Preoperative parenchymal or interstitial lung disease
  • Intracranial hypertension
  • Poor transthoracic acoustic window
  • Obesity
  • Allergy to ultrasound transmission gel
  • Need for single lung ventilation
  • Systemic hypertension on antihypertensive medications

Treatment and study plan

Lung Recruitment Maneuver

Other

Lung Recruitment Maneuver by Anesthesiologist

Fluid Administration

Other

Administration of IV Fluid by Anesthesiologist

Primary outcomes

  1. Change in stroke volume

    Time frame: immediately before and after each intervention

    Evaluate Lung Recruitment Maneuver as a means to predict fluid responsiveness in mechanically ventilated pediatric patients in the operating room.

Secondary outcomes

  1. Change in arterial compliance effect on Systolic Pressure Variation (mmHg)

    Time frame: immediately before and after each intervention

    Evaluate the effect of arterial stiffness on Systolic Pressure Variation (mmHg) in mechanically ventilated pediatric patients in the operating room.

  2. Change in arterial compliance effect on Pulse Pressure Variation (%)

    Time frame: immediately before and after each intervention

    Evaluate the effect of arterial stiffness on Pulse Pressure Variation (%) in mechanically ventilated pediatric patients in the operating room.

  3. Change in arterial compliance effect on Plethysmographic Variability Index (%)

    Time frame: immediately before and after each intervention

    Evaluate the effect of arterial stiffness on Plethysmographic Variability Index (%) in mechanically ventilated pediatric patients in the operating room.

Study contacts

Contact information is provided by the study sponsor or research team.

Viviane Nasr, MD

CONTACT

[email protected]

617-355-6225

Sponsors and collaborators

Lead sponsor

Boston Children's Hospital

Other

Collaborators

  • Masimo Corporation

Registry information

Important dates

Study start
2018
Primary completion
2027
Study completion
2027
First posted
Feb 13, 2018
Registry last updated
Nov 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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