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OpenTrials
Completed

NCT Number: NCT02795208

Lung Recruitment Improves Right Ventricle Performance

This study test whether a lung recruitment maneuver improves the right ventricle performance after cardiopulmonary bypass. Half of the patients received an standard protective ventilation and the other half the same ventilatory pattern after a lung recruitment maneuver.

Completed

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Key information

Conditions

Atelectasis Lung Diseases Pulmonary Atelectasis Respiratory Tract Diseases

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Atelectasis is developed in 90% of anesthetized patients after surgery.

Protective ventilation with low tidal volumes and positive-end expiratory pressure (PEEP) promotes atelectasis with the potential right ventricle dysfunction induced by the increment in afterload (activation of the pulmonary hypoxic vasocontriction reflex).

Lung recruitment can improve the right ventricle performance caused by atelectasis because the pulmonary hypoxic vasocontriction reflex desapear in a normal aerated lungs.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • cardiovascular surgery with cardiopulmonary bypass.
  • Patients with a New York Heart Association (NYHA) class I-II,
  • Pre-operative left ventricular ejection fraction ≥ 50 %.
  • Euroscore ≤ 6.

Exclusion criteria

  • TEE contraindications.
  • Hemodynamically unstable
  • Needi for inotropic support

Treatment and study plan

Lung recruitment maneuver

Procedure

The lung recruitment maneuver consists in a brief and controlled increment in airways pressure (20 cmH2O of PEEP + 20 cmH2O of driving pressure) for 10 breaths.

Primary outcomes

  1. Right ventricle assessment by transesophageal echocardiography

    Time frame: intraoperative

Secondary outcomes

  1. Atelectasis assessment by transesophageal echocardiography

    Time frame: intraoperative

  2. PaO2 and respiratory compliance

    Time frame: intraoperative

Sponsors and collaborators

Lead sponsor

Hospital Privado de Cordoba, Argentina

Other

Registry information

Official study title

Lung Recruitment Improves Right Ventricle Performance After Cardio-Pulmonary Bypass

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jun 10, 2016
Registry last updated
Jun 14, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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