Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100730, China
Location status: Recruiting
Recruiting
NCT Number: NCT07379242
Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is:
Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.
- Oxygenation index < 300 mmHg.
- Patients who are clinically judged by the attending doctor to require the PEEP titration.
Exclusion criteria
- Aged under 18 years.
- Pregnancy.
- Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).
- No informed consent obtained.
- Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.
- High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.
Treatment and study plan
The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT
Diagnostic TestThe patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R/I ratio), with concurrent monitoring by both 2D- and 3D- EIT.
Primary outcomes
-
Lung recruitment assessed by R/I ratio and 2D/3D-EIT （PEEP titration）
Time frame: Within 24 hours post-enrollment
Lung recruitment potential can be predicted by the R/I ratio and the lung collapse rate calculated from 2D/3D-EIT.
Other outcomes
-
R/I ratio measured by 2D/3D-EIT
Time frame: Within 24 hours after enrollment
The R/I ratio can be calculated from 2D/3D-EIT.
-
V/Q monitored by EIT
Time frame: Within 24 hours after enrollment
Ventilation and perfusion monitored by 2D/3D-EIT at different PEEP levels. To evaluate the V/Q match, deadspace and shunt lung region.
-
SpO₂ at different PEEP levels
Time frame: Within 24 hours after enrollment
Pulse oxygen saturation at different PEEP levels
-
Lung compliance at different PEEP levels
Time frame: Within 24 hours after enrollment
Lung compliance at different PEEP levels measured via ventilator parameters
-
Mechanical power
Time frame: Within 24 hours after enrollment
Mechanical power measured via ventilator parameters
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Peking Union Medical College Hospital
Other
Registry information
Official study title
Lung Recruitment Assessed by Two-Dimensional/Three-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
Important dates
- Study start
- 2025
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Jan 30, 2026
- Registry last updated
- Jan 30, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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