Kocaeli University Hospital
Kocaeli, Turkey (Türkiye)
NCT Number: NCT03651817
Respiratory complications range from 8% to 79% of the frequency after open heart surgery where the patient is on-pump operated by cardiopulmonary machine. There were many changes in physiology due to anesthesia and cardiac surgery which cause volume and barotrauma complications with mechanical ventilation. These complications increase cost by prolonging morbidity and morbidity as well as hospital stay. Intraoperative and postoperative mechanical ventilation strategies can prevent these complications. CPB stimulates the systemic inflammatory response to the secretion of neutrophil, endotoxin and proinflammatory cytokines in the complex, increasing the permeability of the capillaries. Although coronary artery bypass graft surgery (CABG) is associated with a 0.4% to 2.0% acute respiratory distress syndrome (ARDS), mortality is quite high. Lung-protective ventilation strategies commonly used for prevention of ARDS. Ferrando et al. have proposed pulmonary ventilation with a tidal volume (TV) of less than 10 mL / kg as a pulmonary intraoperative protective ventilation strategy. Investigators aimed to compare oxygenation and ventilation parameters with respiratory mechanics in patients who underwent open heart surgery and were ventilated with 6 ml / kg tidal volume and 8 ml / kg TV, which were recommended as lung protective ventilation strategies during anesthesia.
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Notify Me18 year–75 year
All sexes
Interventional
Not applicable
Kocaeli, Turkey (Türkiye)
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Patients will be ventilated with anesthesia machine according to the group they belong to
Time frame: from the beginning of operation to 6th hour of post-extubation
Investigators will compare the changes in arterial carbondiokside levels in arterial blood gas samples
Time frame: from the beginning of the operation to the end of the surgery
airway pressures will be continuously assessed
Time frame: from the beginning of the operation to the end of the surgery
Blood pressure will be continuously recorded and assessed due to time intervals
Time frame: from the beginning of the operation to the end of the surgery
Heart rate will be continuously recorded and assessed due to time intervals
Time frame: from the beginning of the operation to the end of the surgery
Continous central venous pressure will ve recorded and assessed due to time intervals
Kocaeli University
Other
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