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Completed

NCT Number: NCT00727714

Lung Function and Inflammatory Markers in Cement Dust Exposed Workers: A Cross-shifts Study

The aim of the study is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours).

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Key information

Conditions

Airway Obstruction Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sykehuset Telemark HF

Skien, N-3710, Norway

About this study

OBJECTIVE:

Cement dust is suspected to be one of the main factors causing increased mortality among workers not only in the cement production industry, but also in the construction industry worldwide. Our aim is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours).

METHODS:

All employees from Norwegian cement plants, are invited to participate. The workers will perform spirometry, single-breath determination of carbon monoxide uptake, blood samples before and after a working shift of 6-8 hours, and again after 24 hours. Information on respiratory symptoms, allergy and former respiratory disease as well as exposure information will be given on a self-reported questionnaire. Changes in lung function indices, nitric oxide levels and serum inflammatory markers will be calculated. Nitric oxide will only be measured in non-smokers. We will compare cement dust exposed workers with low-level or non-exposed workers (controls).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Employees from a Norwegian cement production plant

Exclusion criteria

  • Exhaled nitric oxide measurements: smokers
  • Substantial previous work in quarry or as a miner

Treatment and study plan

Primary outcomes

  1. Changes in Lung Function Measurements During One Work Shift (6-8h)

    Time frame: baseline and 6-8h

    Changes in lung function measurements during one work shift (6-8h), spirometry and gass diffusion capacity

Secondary outcomes

  1. Changes in FeNO Measurements During One Shift (6-8h)

    Time frame: baseline and 6-8h

  2. Changes in Serum/Plasma Inflammatory Markers During One Shift (6-8h)

    Time frame: Baseline and 6-8h

  3. Changes in FeNO Measurements Between Baseline (0h) and 32 h

    Time frame: 0-32h

  4. Changes in Serum/Plasma Inflammatory Markers Between Baseline and 32 h

    Time frame: 0-32h

Sponsors and collaborators

Lead sponsor

Sykehuset Telemark

Other Gov

Collaborators

  • National Institute for Occupational Safety and Health (NIOSH/CDC)
  • Rikshospitalet University Hospital

Registry information

Official study title

Circulating Inflammatory Markers, Exhaled NO and Lung Function in Cement Production Workers; a Cross-shifts Study

Acronym: LIS

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Aug 4, 2008
Registry last updated
May 20, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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