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Completed

NCT Number: NCT04618302

Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Zurich and University Hospital of Zurich

Zurich, 8001, Switzerland

About this study

The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Age 18 yrs and older
  • Ability to follow study procedures and instructions in German

Exclusion criteria

  • Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
  • Obesity (BMI > 30kg/m2)
  • Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
  • Mental impairment leading to inability to cooperate
  • Respiratory infection in the last two weeks
  • Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio < lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Treatment and study plan

Primary outcomes

  1. Diffusing capacity for nitric oxide (DLNO)

    Time frame: At second study visit

    DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

  2. Diffusing capacity for nitric oxide (DLNO)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

Secondary outcomes

  1. Diffusing capacity for nitric oxide (DLNO)

    Time frame: At second study visit

    DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

  2. Diffusing capacity for nitric oxide (DLNO)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

  3. Diffusing capacity for carbon monoxide (DLCO)

    Time frame: At second study visit

    DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

  4. Diffusing capacity for carbon monoxide (DLCO)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

  5. Diffusing capacity for carbon monoxide (DLCO)

    Time frame: At second study visit

    Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

  6. Diffusing capacity for carbon monoxide (DLCO)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

  7. Alveolar volume (VA)

    Time frame: At second study visit

    VA (in L) measured at 50% of the gas exchange threshold during cycling exercise.

  8. Alveolar volume (VA)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    VA (in L) measured at 50% of the gas exchange threshold during cycling exercise.

  9. Alveolar volume (VA)

    Time frame: At second study visit

    Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise.

  10. Alveolar volume (VA)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise.

  11. Breath hold time (BHT)

    Time frame: At second study visit

    BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise.

  12. Breath hold time (BHT)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise.

  13. Breath hold time (BHT)

    Time frame: At second study visit

    BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise.

  14. Breath hold time (BHT)

    Time frame: At third study visit, approximately 1-2 weeks after second study visit

    BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise.

Sponsors and collaborators

Lead sponsor

Thomas Radtke

Other

Registry information

Official study title

Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise

Important dates

Study start
2020
Primary completion
2020
Study completion
2021
First posted
Nov 5, 2020
Registry last updated
Apr 19, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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