Lung Cancer Screening in HIgh Risk nonsmokErs by Artificial inteLligence Device

Inclusion criteria

Patients are eligible to be included in the study only if all of the following criteria apply:

• Age 50-75 years old
• Non-smoker (defined as less than 100 cigarettes in lifetime)
• Having a first-degree family history of lung cancer
• Physically fit for curative treatment if early-staged lung cancer is found
• Able to provide written informed consent
• Consent to follow up visits and follow up CT scan if indicated
• Consent to blood taking for translational research

Exclusion criteria

Patients who meet any of the following exclusion criteria at screening are not eligible to be enrolled in this study:

• History of malignancy
• Smoking history (defined as more than 100 cigarettes in lifetime)
• Clinical symptoms suspicious for lung cancer e.g. haemoptysis, chest pain, weight loss
• Medical comorbidities that preclude curative treatment (surgery) for lung cancer, such as severe heart disease, acute or chronic respiratory failure, home oxygen therapy, bleeding disorder
• Pregnant ladies or ladies planning for conception
• History of tuberculosis or interstitial lung disease
• Pneumonia requiring antibiotic treatment within the last 12 weeks
• CT thorax or chest performed within 2 years (including LDCT, PET-CT, MRI thorax or suspicious of lung cancer)
• Unable or unwilling to provide written informed consent