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OpenTrials
Completed

NCT Number: NCT06133816

Lung Cancer Screening Eligibility Assessment

The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help inform the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

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Key information

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

About this study

Despite growing evidence that lung cancer screening (LCS) reduces lung cancer-specific mortality, LCS across the United States is remarkably low. This is due in part to challenges with identifying adults who meet eligibility criteria for lifetime smoking intensity (i.e., 20 pack-years or greater), which is often missing from the electronic medical record. We have developed a simplified eligibility tool that has shown accuracy in estimating pack-years. But given the potential for low response rates, there is a great need to identify effective strategies to increasing response rates equitably prior to using it in practice or in future studies. The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help to identify the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • meet age eligibility (50-80 years old) for LCS based on 2021 USPSTF guidelines; and
  • have completed at least one primary care visit at Penn Medicine in 2020-2025

Exclusion criteria

  • have a documented history of lung cancer;
  • have a documented history of completing LCS at Penn Medicine;
  • are listed as not wanting to be contacted or solicited for research; or
  • do not otherwise meet inclusion criteria.

Treatment and study plan

Framed Introductory Message A

Behavioral

Randomly assign patients to receive introductory message encouraging them to complete the survey (version A).

Framed Introductory Message B

Behavioral

Randomly assign patients to receive introductory message encouraging them to complete the survey (version B).

Framed Introductory Message C

Behavioral

Randomly assign patients to receive introductory message encouraging them to complete the survey (version C).

Framed Tobacco Use Message A

Behavioral

Randomly assign patients to receive norming message related to tobacco use (version A).

Framed Tobacco Use Message B

Behavioral

Randomly assign patients to receive norming message related to tobacco use (version B).

Financial incentive

Behavioral

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Primary outcomes

  1. Full Survey Completion

    Time frame: 7 days

    The proportion of participants that answers all three survey questions via text message among all those randomized.

Secondary outcomes

  1. Partial Survey Completion

    Time frame: 7 days

    The proportion of participants that answer at least one of three survey questions via text message among all those randomized.

Sponsors and collaborators

Lead sponsor

Abramson Cancer Center at Penn Medicine

Other

Collaborators

  • National Cancer Institute (NCI)
  • National Institutes of Health (NIH)

Registry information

Official study title

Using a Simplified Tool to Predict Lung Cancer Screening (LCS) Eligibility: Experiment to Test Effects of Messaging on Response Rates

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Nov 18, 2023
Registry last updated
May 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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