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OpenTrials
Completed

NCT Number: NCT04614129

Lung Cancer Risk and Early Detection in Firefighters

This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

Completed

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 40-80 years of age or with 10 years of firefighting experience
  • Current or retired firefighters
  • No personal history of lung cancer
  • Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study

Exclusion criteria

  • Any active cancer (undergoing treatment or diagnosed within the past 5 years)

Treatment and study plan

Low dose CT

Diagnostic Test

All participants will have a low dose chest CT either within one year of enrollment or after enrollment

Other names: LDCT

Primary outcomes

  1. Nodule detection rate

    Time frame: 12 months

    Frequency of nodule detection

  2. High-risk nodule detection rate

    Time frame: 12 months

    Frequency of high-risk nodule detection. High risk is defined as a Lung RADS of 3 or 4. Lung RADS categories are as follows: 0) Incomplete; 1) Negative; 2) Benign appearance or behavior; 3) Probably benign; 4) Suspicious

Secondary outcomes

  1. Interstitial lung disease detection rate

    Time frame: 12 months

    Frequency of interstitial lung disease detection

  2. Coronary artery calcification (CAC) ordinal scores

    Time frame: 12 months

    Frequency of high coronary artery calcification (CAC) ordinal scores. Possible scores range from 0 to 12 and high scores are defined as those greater than or equal to 10

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Registry information

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Nov 3, 2020
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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