University Children's Hospital Zürich
Zurich, 8032, Switzerland
NCT Number: NCT03659838
This study assessed the respiratory health of schoolchildren from the canton of Zurich by combining self-reported information on respiratory symptoms with lung function test results and air pollution measurements.
Luftibus in the school (LUIS) is a population-based study conducted in the canton of Zurich, Switzerland. Between the years 2013 and 2016 a bus with equipment for lung function testing and air pollution measurement visited numerous schools across the canton Zurich. The parents of the schoolchildren filled in a questionnaire with validated questions on upper and lower respiratory symptoms, trigger factors, diagnosis, treatment of respiratory symptoms, health behavior and environmental factors. The children were interviewed using a shorter questionnaire. Fieldworkers measured lung function (spirometry and double tracer gas single-breath washout) and an airway inflammation test (fractional exhaled nitric oxide) in the bus. The recruited population included 3500 schoolchildren aged 6 to 16 years from the canton of Zurich.
Respiratory symptoms and their influence on physical activity and sleep have a strong impact on children's quality of life and school performance. The results of this study will provide new insights on schoolchildren's respiratory health that may help to establish new recommendations and influence policy makers' decisions.
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Notify Me6 year–16 year
All sexes
Observational
Zurich, 8032, Switzerland
Background:
Few population-based studies have recently investigated the epidemiology of childhood respiratory symptoms in Switzerland.
Objectives:
The Luftibus in the school study was setup to assess the respiratory health of schoolchildren from the canton of Zurich and to investigate relationships between respiratory symptoms, lung function and air pollution.
Methods:
Recruitment and participation:
All schools in the canton of Zürich were invited to participate in the LUIS study. Those schools interested in participating were approached. The eligible study population were children aged 6 to 16 years with parental consent from the schools that agreed to participate. Prior to each school visit, parents received a letter with information about the project, an informed consent form and a questionnaire. During the school visit, trained field workers performed lung function tests in children at the school, interviewed the children using a short questionnaire and collected the parental questionnaires. A subsample of the schools was visited again one year after the first visit in order to collect follow-up information, using the same procedure and gathering the same measurements.
Information collected:
Study database:
The study questionnaire database was created using Epidata, which allows data entry and data extraction in CVS format.
Funding:
Lung League of Zurich
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Time frame: At baseline
Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using parent questionnaires.
Time frame: At baseline
Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using participant questionnaires.
Time frame: At baseline
Forced expiratory volume in 1 second (FEV1) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Time frame: At baseline
Forced vital capacity (FVC) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Time frame: At baseline
Slope from the tidal (alveolar) phase III (SIII) from double-tracer gas single-breath washout test curves.
Time frame: At baseline
Airway inflammation measured by levels of fractional concentration of exhaled nitric oxide.
Time frame: One year after baseline
Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using parent questionnaires.
Time frame: One year after baseline
Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using participant questionnaires.
Time frame: One year after baseline
Forced expiratory volume in 1 second (FEV1) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Time frame: One year after baseline
Forced vital capacity (FVC) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Time frame: One year after baseline
Slope from the tidal (alveolar) phase III (SIII) from double-tracer gas single-breath washout test curves.
Time frame: One year after baseline
Airway inflammation measured by levels of fractional concentration of exhaled nitric oxide.
University Children's Hospital, Zurich
Other
Luftibus in the School: a Population-based Study of Respiratory Symptoms, Lung Function and Air Pollution.
Acronym: LUIS
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