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NCT Number: NCT07440615

Lower-Limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females

The aim of this study will be to examine the relationship between leg muscle mass and muscle strength, aerobic capacity, anaerobic power, and jumping performance in young adults. In addition, these physical performance measures will be compared between male and female participants.

Recreationally active young adults will be recruited to participate in the study. Body weight and leg muscle mass will be assessed using a body composition analyzer. Participants will perform isokinetic and isometric leg strength tests, an aerobic fitness test (VO₂max), an anaerobic power test (Wingate), and a countermovement jump (CMJ) test.

This study aims to improve the understanding of the effects of leg muscle mass on physical performance and to identify possible differences between males and females. The findings are expected to contribute to exercise prescription, performance assessment, and future research in sports and health sciences.

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Key information

Conditions

Physical Performance Aerobic Capacity Anaerobic Power Jumping Performance in Young Adults Leg Muscle Mass Muscle Strength

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Aeromedical Research and Training Center (ARTC)

Eskişehir, 26000, Turkey (Türkiye)

Location status: Recruiting

Location contact

Tuncay ALPARSLAN, Assoc. Prof.

CONTACT

[email protected]

+905058221661

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • absent of lower body injuries that could impact testing;
  • were moderately physically active
  • did not ingest ergogenic aids or stimulant drugs for at least 6 months prior to the start of the study.

Exclusion criteria

-

Treatment and study plan

Physical Performance Assessment

Other

Muscle Isokinetic Strength Testing, Leg Muscle Mass, and Aerobic and Anaerobic Performance Testing, Contermovement Jump

Primary outcomes

  1. Leg Muscle Mass-Related Physical Performance Measures

    Time frame: Baseline

    Measurement tool: Bioelectrical Impedance Analyzer (InBody 270, Biospace Co., South Korea) Description: Segmental lower-limb muscle mass (kg) measured using multi-frequency bioelectrical impedance analysis.

    Unit: kg Time Frame: Baseline (single assessment)

  2. Muscle Isokinetic Strength

    Time frame: Baseline

    Measurement tool: Isokinetic dynamometer (Humac Norm, Computer Sports Medicine Inc., USA) Description: Peak torque of dominant leg knee flexors and extensors measured at 60°·s-¹ and normalized to body weight.

    Unit: Nm·kg-¹ Time Frame: Baseline

  3. Anaerobic Power

    Time frame: Baseline

    Measurement tool: Wingate Anaerobic Test performed on cycle ergometer (Wattbike WPM Model B, UK) Description: Relative peak anaerobic power calculated during 30-s Wingate test and normalized to body weight.

    Unit: W·kg-¹ Time Frame: Baseline

  4. Countremovement Jump

    Time frame: Baseline

    Measurement tool: SmartJump contact mat system (Fusion Sport, Queensland, Australia) Description: Vertical jump height measured during the Countermovement Jump test. Jump height is calculated automatically from flight time using the SmartJump performance measurement system.

    Scale description: Countermovement Jump Height (centimeters). Typical physiological range in healthy young adults is approximately 10-60 cm.

    Interpretation: Higher values indicate better lower-body explosive performance. Unit: cm Time Frame: Baseline (up to 8 weeks)

  5. Aerobic Capacity

    Time frame: Baseline

    Measurement tool: Breath-by-breath metabolic gas analyzer (Cosmed Quark CPET) during Bruce treadmill protocol Description: Maximal oxygen consumption determined according to standard VO₂max criteria.

    Unit: ml·kg-¹·min-¹ Time Frame: Baseline

  6. Muscle Isometric Strength

    Time frame: Baseline

    Measurement tool: Leg dynamometer (Takei T.K.K. 5402, Takei Scientific Instruments, Japan) Description: Maximal voluntary isometric force normalized to body weight. Highest value of three trials recorded.

    Unit: kg·kg-¹ Time Frame: Baseline

Study contacts

Contact information is provided by the study sponsor or research team.

Tuncay ALPARSLAN, Assoc.Prof.

CONTACT

[email protected]

Türkiye ext. 5058221661

Sponsors and collaborators

Lead sponsor

Uludag University

Other

Registry information

Official study title

The Relationship Between Lower-limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females.

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 27, 2026
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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