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Completed

NCT Number: NCT03587051

Low Versus High-glycemic Index Post-exercise Diets for Improving Metabolism and Body Composition

Postprandial triglycerides are a strong risk factor for heart disease. The purpose is to assess the effects of a low-glycemic versus high-glycemic meal after 90 minute exercise sessions that are done 4 times a week for 6 weeks on postprandial triglyceride level. Secondary measurements include other lipids and body composition.

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Key information

Age range

18 year–44 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Saskatchewan

Saskatoon, Saskatchewan, S7N 5B2, Canada

About this study

The increase in triglycerides after a meal (i.e. postprandial triglycerides) is a strong risk factor for cardiovascular disease. Overweight/obese individuals have a greater triglyceride response to the same meal compared to lean individuals; therefore they are at greater risk. If exercise is performed the evening before a high-fat breakfast, the postprandial levels of triglycerides after the breakfast are reduced; however, if high glycemic index (GI) foods are consumed after the exercise session, the benefits of exercise on next-day postprandial triglycerides is negated. The investigators recently showed (HSFC funded) that consuming low GI foods after exercise is similar to fasting after exercise and superior to consumption of high GI foods for lowering next-day postprandial triglycerides. Low GI food was also superior for increasing fat oxidation, and lowering insulin, and low and very low density lipoproteins and preventing a decrease in high density lipoproteins. The benefits of an acute exercise session followed by low GI food consumption is now clear; however, it is not known whether this practice over weeks of exercise training results in accumulated and sustained benefits.

The purpose of this study is to determine the chronic effects of consuming low compared to high GI foods after exercise sessions over six weeks in overweight and obese individuals.

Twenty-four overweight and obese males and females will be randomized to consume either high or low GI foods immediately after exercise sessions (four sessions per week, 90 minutes per session, six weeks). At all other times of the day over the six weeks, they will be supplied a moderate GI diet, with calories and macronutrients based on four-day food diaries completed before the study. Two weeks before the intervention, participants will be required to go on the moderate GI diet, as a lead-in. One week into the lead-in, a baseline test will be done to determine postprandial metabolic responses (i.e. triglycerides, low and very low density lipoproteins, high density lipoproteins, insulin, and fat oxidation) after a morning high-fat breakfast. A week later, the same postprandial testing will be carried out the morning after the first exercise and post-exercise consumption of a low or high GI recovery meal. Participants will continue the training and post-exercise food consumption for the next six weeks, with postprandial measures taken again following the final exercise and feeding session. Body composition and aerobic fitness will be determined before and after the six week intervention.

The investigators hypothesize that the low GI post-exercise feeding will be superior to the high GI post-exercise feeding for reducing body fat, improving fat oxidation, and reducing postprandial triglycerides, insulin and other harmful lipids. The results of the study will provide clinicians, exercise professionals and dietitians unique and experimentally tested strategies for their clients to lose body fat and improve metabolic profiles, to reduce the risk of heart disease.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Overweight or obese (BMI 25 or greater)

Exclusion criteria

  • Smokers
  • Diabetic
  • Taking medications that affect carbohydrate or lipid metabolism

Treatment and study plan

Low glycemic index post-exercise diet

Dietary Supplement

Feeding of a low-glycemic index, lentil meal after 90 minutes of walking exercise

High glycemic index post-exercise diet

Dietary Supplement

Feeding of a high-glycemic index meal (i.e. instant mashed potatoes, white bread, egg whites) after 90 minutes of walking exercise

Primary outcomes

  1. Postprandial triglycerides

    Time frame: Change from baseline to 1 week and 6 weeks

    Triglyceride from serum

Secondary outcomes

  1. Postprandial cholesterol

    Time frame: Change from baseline to 1 week and 6 weeks

    Cholesterol from serum

  2. Postprandial low density lipoprotein

    Time frame: Change from baseline to 1 week and 6 weeks

    Low density lipoprotein from serum

  3. Postprandial high density lipoprotein

    Time frame: Change from baseline to 1 week and 6 weeks

    High density lipoprotein from serum

  4. Postprandial glucose

    Time frame: Change from baseline to 1 week and 6 weeks

    Glucose from serum

  5. Postprandial insulin

    Time frame: Change from baseline to 1 week and 6 weeks

    Insulin from serum

  6. Fasting Triglyceride

    Time frame: Change from baseline to 1 week and 6 weeks

    Triglyceride from serum

  7. Fasting cholesterol

    Time frame: Change from baseline to 1 week and 6 weeks

    Cholesterol from serum

  8. Fasting LDL-cholesterol

    Time frame: Change from baseline to 1 week and 6 weeks

    LDL from serum

  9. Fasting HDL-cholesterol

    Time frame: Change from baseline to 1 week and 6 weeks

    HDL from serum

  10. Fasting glucose

    Time frame: Change from baseline to 1 week and 6 weeks

    Glucose from serum

  11. Fasting Insulin

    Time frame: Change from baseline to 1 week and 6 weeks

    Insulin from serum

  12. Postprandial fat oxidation

    Time frame: Change from baseline to 1 week and 6 weeks

    Fat oxidation assessed by expiratory gases

  13. Fat mass

    Time frame: Change from baseline to 6 weeks

    Fat mass assessed by dual energy x-ray absorptiometry

  14. Waist Girth

    Time frame: Change from baseline to 6 weeks

    Waist girth assessed by a measurement tape

Sponsors and collaborators

Lead sponsor

University of Saskatchewan

Other

Collaborators

  • Heart and Stroke Foundation of Canada

Registry information

Official study title

Endurance Training and Post-exercise Low Glycemic Index Recovery Diet for Improving Postprandial Triglycerides

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jul 16, 2018
Registry last updated
Jun 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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