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OpenTrials
Completed

NCT Number: NCT05695053

Low Level Laser Therapy Applied in Orthodontic Tooth Movement

Currently, orthodontic treatment takes 2-3 years.. If we accelerate tooth movement by low energy laser therapy, we could reduce treatment time. Low Level Laser Therapy(LLLT) applied in Orthodontic Tooth Movement, which stimulates formation of osteoclast-like cells expression in vitro. Osteoclast can be served as an index for tooth movement. Increasing the number of osteoclast will increase bone formation and tooth movement. We plan to find a useful clinical protocol to improve the efficiency of orthodontic tooth movement. Test low energy laser in vitro. Find an effective wavelength and irradiation time to stimulate formation of osteoclast. Develop an useful protocol that clinical orthodontist could follow and reduce orthodontic treatment time.

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Key information

Conditions

Orthodontic Appliance Complication

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

China Medical University Hospital

Taichung, 40402, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with good oral hygiene
  • 18 years old
  • Patients who required bilateral canine retraction into the extracted premolar

Exclusion criteria

  • Serious medical history
  • Poor oral hygiene
  • Previous orthodontic treatment
  • Orthognathic surgery or syndromic patients

Treatment and study plan

Low Level Laser Therapy

Device

Low level laser therapy could provide energy to trigger cell differentiation.

Placebo

Other

Placebo

Primary outcomes

  1. Orthodontic tooth movement

    Time frame: 1-6month

    the distance between canine and premolar

Secondary outcomes

  1. bone density after Orthodontic tooth movement

    Time frame: 1-6month

    bone density change around canine

Sponsors and collaborators

Lead sponsor

China Medical University Hospital

Other

Registry information

Important dates

Study start
2021
Primary completion
2022
Study completion
2023
First posted
Jan 23, 2023
Registry last updated
Feb 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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