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Completed

NCT Number: NCT06756854

Low-Level Laser Therapy and Injectable Platelet-Rich Fibrin for Thin Gingival Phenotype.

Management of thin gingival phenotype using non-surgical methods (injection of liquid platelet rich fibrin and exposure to low level laser therapy

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Key information

Conditions

Periodontal Diseases Mouth Diseases Stomatognathic Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Alaa Elsayed

Cairo, Egypt

About this study

Thin gingival phenotype can lead to recession and root exposure. Liquid prf can be obtained by centrifugion of blood sample on speed 700 rpm for 3 min, then injection of this liquid in the attached gingiva and muco-gingival junction (3 times with 7 days interval) for the first group. The second group will be injected with I-PRF in the same method in addition to exposure to Low Level Laser therapy (after each injection of I-PRF). This method is expected to increase the thickness of the gingiva.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • free systimatically good oral hygiene gingival thickness less than 1mm

Exclusion criteria

  • pregnancy or lactation pereiodontitis periodontal surgery orthodontic ttt tooth mobility,bruxism,crowding,missing or supernumerary teeth smoking

Treatment and study plan

Biologic Agent: injectable platelet rich fibrin.

Biological

injection of I-PRF to thin gingival phenotype 3 times with 7 days interval between sessions.

Other names: Liquid platelet rich fibrin

injecable platelet rich fibrin, and low level laser therapy radiation.

Other

injection of I-PRF+ exposure to LLLT to thin gingival phenotype 3 times with 7 days interval between sessions.

Primary outcomes

  1. Gingival thickness improvement in millimeters.

    Time frame: 6 months after treatment

    clinical parameter

  2. Keratinized tissue width improvement in millimeters.

    Time frame: 6 months after treatment

    Clinincal parameter.

Secondary outcomes

  1. Improvement of gingival index.

    Time frame: 6 months after treatment

    Clinical parameter.

  2. Improvement of bleeding on probing.

    Time frame: 6 months after treatment

    Clinical parameter.

  3. Improvement of sulcus depth.

    Time frame: 6 months after treatment

    Clinical parameter.

Sponsors and collaborators

Lead sponsor

Faculty of Dental Medicine for Girls

Other Gov

Registry information

Official study title

Evaluation of Low-Level Laser Therapy as Adjunctive to the Injectable Platelet-Rich Fibrin in the Management of Patients With Thin Gingival Phenotype.

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 3, 2025
Registry last updated
Jan 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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